Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.72 |
| ▸ | BTK | Q06187 | 5/20 | 0.70 |
| ▸ | ITK | Q08881 | 3/20 | 0.66 |
| ▸ | SYK | P43405 | 2/20 | 0.63 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | LYN | P07948 | 1/20 | 0.55 |
| ▸ | TEC | P42680 | 1/20 | 0.55 |
| ▸ | TXK | P42681 | 1/20 | 0.55 |
| ▸ | BMX | P51813 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | CD69 | Q07108 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23409017 | 0.86 | SYK (0.68) | EGFRBTKITKSYKAURKA | |
| SCHEMBL13167027 | 0.86 | EGFR (0.83) | EGFRBTKITKJAK2LYN | |
| SCHEMBL29722353 | 0.84 | EGFR (1.00) | EGFRBTKITKSYKJAK2 | |
| SCHEMBL12519669 | 0.84 | EGFR (1.00) | EGFRBTKITKJAK2LYN | |
| SCHEMBL12519855 | 0.84 | EGFR (1.00) | EGFRBTKITKSYKJAK2 | |
| SCHEMBL29722535 | 0.84 | EGFR (1.00) | EGFRBTKITKJAK2LYN | |
| SCHEMBL12519588 | 0.84 | EGFR (0.72) | EGFRBTKITKSYK | |
| SCHEMBL12519856 | 0.83 | EGFR (0.79) | EGFRBTKITKSYKJAK2 | |
| SCHEMBL20216169 | 0.83 | EGFR (0.80) | EGFRBTKITKSYKJAK2 | |
| SCHEMBL12519857 | 0.83 | EGFR (1.00) | EGFRBTKITKSYKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3549934-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | Celgene CAR LLC (BM) | 2019-10-09 | — | — | EP | disclosed |