Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 4/20 | 0.77 |
| ▸ | EGFR | P00533 | 8/20 | 0.72 |
| ▸ | BTK | Q06187 | 5/20 | 0.72 |
| ▸ | ULK1 | O75385 | 2/20 | 0.68 |
| ▸ | SYK | P43405 | 2/20 | 0.63 |
| ▸ | AURKA | O14965 | 2/20 | 0.61 |
| ▸ | CDK1 | P06493 | 1/20 | 0.60 |
| ▸ | CDK4 | P11802 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12519451 | 0.84 | EGFR (1.00) | PTK2EGFRBTK | |
| SCHEMBL29722381 | 0.84 | EGFR (1.00) | PTK2EGFRBTK | |
| SCHEMBL29575102 | 0.84 | ULK1 (0.68) | PTK2EGFRBTKULK1SYK | |
| SCHEMBL17544883 | 0.84 | ULK1 (0.68) | PTK2EGFRBTKULK1SYK | |
| SCHEMBL24486552 | 0.83 | EGFR (0.81) | PTK2EGFRBTKULK1SYK | |
| SCHEMBL17547575 | 0.83 | EGFR (0.64) | PTK2EGFRBTKULK1SYK | |
| SCHEMBL17547564 | 0.83 | EGFR (0.64) | PTK2EGFRBTKULK1SYK | |
| SCHEMBL17544374 | 0.81 | ULK1 (1.00) | PTK2EGFRBTKULK1SYK | |
| SCHEMBL17544699 | 0.81 | ULK1 (0.92) | PTK2EGFRBTKULK1SYK | |
| SCHEMBL12519518 | 0.81 | EGFR (1.00) | PTK2EGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3549934-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | Celgene CAR LLC (BM) | 2019-10-09 | — | — | EP | disclosed |