SCHEMBL2144408

SCHEMBL2144408

CCCC[Si](C)(C)OC(=O)/C=C/C(=O)OC

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 6/20 0.46
KEAP1 Q14145 1/20 0.46
NFE2L2 Q16236 1/20 0.46
ATM Q13315 1/20 0.41
MAPT P10636 1/20 0.36
RAB9A P51151 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
GFPT1 Q06210 1/20 0.36
EPHX1 P07099 1/20 0.35
POLB P06746 1/20 0.34
POLA1 P09884 1/20 0.34
ZDHHC20 Q5W0Z9 2/20 0.34
ZDHHC2 Q9UIJ5 2/20 0.34
EPHX2 P34913 1/20 0.33
TRPV1 Q8NER1 1/20 0.32
HPGD P15428 1/20 0.32
TSHR P16473 1/20 0.32
ACHE P22303 1/20 0.32
PRKCA P17252 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2144414 1.00 HCAR2 (0.46) HCAR2KEAP1NFE2L2ATMMAPT
SCHEMBL28365521 0.93 ATM (0.47) HCAR2KEAP1NFE2L2ATMMAPT
SCHEMBL28365427 0.93 ATM (0.47) HCAR2KEAP1NFE2L2ATMMAPT
SCHEMBL28575319 0.86 HCAR2 (0.53) HCAR2ATMACHE
SCHEMBL29895893 0.83 ATM (0.67) HCAR2ATMMAPTRAB9ANPSR1
SCHEMBL2144391 0.81 HCAR2 (0.54) HCAR2KEAP1NFE2L2ATMMAPT
SCHEMBL2144396 0.81 HCAR2 (0.54) HCAR2KEAP1NFE2L2ATMMAPT
SCHEMBL28365520 0.81 ATM (0.40) HCAR2KEAP1NFE2L2ATMMAPT
SCHEMBL4644433 0.79 ATM (0.36) HCAR2ATMEPHX1HPGDTSHR
SCHEMBL4642160 0.79 ATM (0.36) HCAR2ATMEPHX1HPGDTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2348077-B1 Antifouling composition JOTUN AS (NO) 2013-04-03 EP disclosed
WO-2011092143-A1 ANTIFOULING COMPOSITION JOTUN A/S (NO) 2011-08-04 WO disclosed
EP-2348077-A1 Antifouling composition Jotun A/S (NO) 2011-07-27 EP disclosed
EP-0802243-B1 Coating composition NOF CORP (JP) 2001-06-27 EP disclosed
US-5795374-A SILYL ACRYLATE POLYMERS NOF CORPORATION (JP) 1998-08-18 US disclosed
EP-0802243-A2 Coating composition NOF CORPORATION (JP) 1997-10-22 EP disclosed