SCHEMBL2144396

SCHEMBL2144396

CC[Si](C)(C)OC(=O)C=CC(=O)OC

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 4/20 0.54
NFE2L2 Q16236 4/20 0.54
KEAP1 Q14145 1/20 0.54
GFPT1 Q06210 1/20 0.36
KDM4E B2RXH2 3/20 0.34
ALDH1A1 P00352 3/20 0.34
MAPT P10636 3/20 0.34
TDP1 Q9NUW8 1/20 0.34
ATM Q13315 1/20 0.33
LMNA P02545 3/20 0.33
HTT P42858 2/20 0.33
KMT2A Q03164 2/20 0.33
MEN1 O00255 1/20 0.33
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
TYR P14679 1/20 0.32
CA7 P43166 1/20 0.32
CA9 Q16790 1/20 0.32
CA14 Q9ULX7 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2144391 1.00 HCAR2 (0.54) HCAR2NFE2L2KEAP1GFPT1KDM4E
SCHEMBL7778232 0.83 HCAR2 (0.52) HCAR2NFE2L2KEAP1KDM4EALDH1A1
SCHEMBL2144414 0.81 HCAR2 (0.46) HCAR2NFE2L2KEAP1GFPT1MAPT
SCHEMBL2144408 0.81 HCAR2 (0.46) HCAR2NFE2L2KEAP1GFPT1MAPT
SCHEMBL15186537 0.78 NFE2L2 (0.65) HCAR2NFE2L2KEAP1GFPT1KDM4E
SCHEMBL2144386 0.78 NFE2L2 (0.65) HCAR2NFE2L2KEAP1GFPT1KDM4E
SCHEMBL15186306 0.78 NFE2L2 (0.65) HCAR2NFE2L2KEAP1GFPT1KDM4E
SCHEMBL2144101 0.78 NFE2L2 (0.65) HCAR2NFE2L2KEAP1GFPT1KDM4E
SCHEMBL2144096 0.78 NFE2L2 (0.65) HCAR2NFE2L2KEAP1GFPT1KDM4E
SCHEMBL4644351 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2348077-B1 Antifouling composition JOTUN AS (NO) 2013-04-03 EP disclosed
WO-2011092143-A1 ANTIFOULING COMPOSITION JOTUN A/S (NO) 2011-08-04 WO disclosed
EP-2348077-A1 Antifouling composition Jotun A/S (NO) 2011-07-27 EP disclosed
EP-0802243-B1 Coating composition NOF CORP (JP) 2001-06-27 EP disclosed
US-5795374-A SILYL ACRYLATE POLYMERS NOF CORPORATION (JP) 1998-08-18 US disclosed
EP-0802243-A2 Coating composition NOF CORPORATION (JP) 1997-10-22 EP disclosed