Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 11/20 | 0.83 |
| ▸ | AURKA | O14965 | 1/20 | 0.83 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.83 |
| ▸ | NEK2 | P51955 | 1/20 | 0.68 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.64 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.56 |
| ▸ | MET | P08581 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25550361 | 0.92 | AXL (0.70) | AXLAURKAAURKBNEK2PTK2 | |
| Dubermatinib SCHEMBL29394359 | 0.91 | AXL (1.00) | AXLAURKAAURKBNEK2PTK2 | |
| SCHEMBL21446913 | 0.91 | AXL (0.87) | AXLAURKAAURKBNEK2PTK2 | |
| Dubermatinib SCHEMBL12813478 | 0.91 | AXL (1.00) | AXLAURKAAURKBNEK2PTK2 | |
| SCHEMBL24727537 | 0.90 | AXL (0.86) | AXLAURKAAURKBNEK2PTK2 | |
| SCHEMBL21446889 | 0.89 | AXL (0.66) | AXLAURKAAURKBNEK2PTK2 | |
| SCHEMBL22872062 | 0.88 | AXL (0.79) | AXLAURKAAURKBNEK2PTK2 | |
| SCHEMBL22872061 | 0.88 | AXL (0.79) | AXLAURKAAURKBNEK2PTK2 | |
| SCHEMBL31173448 | 0.85 | AXL (0.75) | AXLAURKAAURKBNEK2PTK2 | |
| SCHEMBL25838209 | 0.85 | AXL (0.75) | AXLAURKAAURKBNEK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230165857-A1 | AXL KINASE INHIBITORS AND USE OF THE SAME | SUMITOMO PHARMA ONCOLOGY, INC. | 2023-06-01 | — | — | US | disclosed |
| US-20230165857-A1 | AXL KINASE INHIBITORS AND USE OF THE SAME | SUMITOMO PHARMA ONCOLOGY, INC. | 2023-06-01 | — | — | US | disclosed |
| US-20210205304-A1 | AXL KINASE INHIBITORS AND USE OF THE SAME | SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. (US) | 2021-07-08 | — | — | US | disclosed |
| US-11013741-B1 | AXL kinase inhibitors and use of the same | SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. (US) | 2021-05-25 | — | — | US | disclosed |
| US-10888562-B1 | — | — | 2021-01-12 | — | — | US | disclosed |
| WO-2019195753-A1 | AXL KINASE INHIBITORS AND USE OF THE SAME | TOLERO PHARMACEUTICALS, INC. (US) | 2019-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11013741-B1 | AXL kinase inhibitors and use of the same | AXL, FLT3, TEC | AXL 1/4885AURKA 100/4885AURKB 167/4885 |
| US-20210205304-A1 | AXL KINASE INHIBITORS AND USE OF THE SAME | AXL, FLT3, TEC | AXL 1/4885AURKA 81/4885AURKB 146/4885 |
| US-20230165857-A1 | AXL KINASE INHIBITORS AND USE OF THE SAME | AXL, FLT3, TEC | AXL 1/4885AURKA 94/4885AURKB 164/4885 |
| US-10888562-B1 | — | TP53, TARBP2, FLT3 | AXL 927/4885AURKA 590/4885AURKB 1490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.