Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.37 |
| ▸ | CDK2 | P24941 | 4/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2144923 | 0.92 | CHEK1 (0.46) | CHEK1CCNA2CDK2CCNA1ADORA2A | |
| SCHEMBL2143944 | 0.92 | GABRA1 (0.39) | KDM4EMAPK1HSD17B10L3MBTL1HRH4 | |
| SCHEMBL2771516 | 0.80 | KDM4E (0.40) | KDM4EMAPK1HSD17B10L3MBTL1CDK2 | |
| SCHEMBL2772868 | 0.80 | KDM4E (0.40) | KDM4EMAPK1HSD17B10L3MBTL1CDK2 | |
| SCHEMBL2144859 | 0.78 | CHEK1 (0.40) | CHEK1CCNA2CDK2CCNA1HRH4 | |
| SCHEMBL2144766 | 0.77 | KDM4E (0.39) | KDM4EMAPK1HSD17B10L3MBTL1 | |
| SCHEMBL3304442 | 0.71 | PTK2 (0.43) | CHEK1CCNA2CDK2CCNA1ADORA2A | |
| SCHEMBL2144921 | 0.70 | CHEK1 (0.49) | CHEK1CCNA2CDK2CCNA1ADORA2A | |
| SCHEMBL3305316 | 0.70 | CHEK1 (0.46) | CHEK1CCNA2CDK2CCNA1ADORA2A | |
| SCHEMBL2511402 | 0.69 | HRH4 (0.34) | CHEK1CCNA2CDK2CCNA1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-B1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2016-04-20 | — | — | EP | claimed |
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | claimed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | claimed |
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | disclosed |