Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.39 |
| ▸ | JAK3 | P52333 | 12/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 12/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | ETV6 | P41212 | 2/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2145354 | 0.89 | JAK2 (0.40) | JAK2JAK3PTK2IDH2CSNK2A1 | |
| SCHEMBL3309853 | 0.84 | JAK2 (0.38) | JAK2JAK3PTK2 | |
| SCHEMBL2144632 | 0.80 | JAK2 (0.37) | JAK2JAK3PTK2 | |
| SCHEMBL2144764 | 0.80 | KIT (0.46) | JAK2JAK3PTK2 | |
| SCHEMBL3307376 | 0.80 | JAK2 (0.43) | JAK2JAK3PTK2 | |
| SCHEMBL13392671 | 0.79 | CDK2 (0.46) | JAK2JAK3PTK2BRD4CSNK2A1 | |
| SCHEMBL13391687 | 0.79 | EML4 (0.40) | JAK2JAK3PTK2BRD4CSNK2A1 | |
| SCHEMBL3309578 | 0.76 | JAK2 (0.36) | JAK2JAK3PTK2 | |
| SCHEMBL13392641 | 0.76 | JAK2 (0.39) | JAK2JAK3PTK2BRD4 | |
| SCHEMBL2144106 | 0.76 | JAK2 (0.42) | JAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | claimed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | claimed |
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | disclosed |