Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.82 |
| ▸ | NPC1 | O15118 | 4/20 | 0.82 |
| ▸ | TSHR | P16473 | 2/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.57 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31504022 | 1.00 | RAB9A (0.82) | RAB9ANPC1TSHRKMT2AMEN1 | |
| SCHEMBL21450364 | 0.89 | RAB9A (0.66) | RAB9ANPC1TSHRKMT2AMEN1 | |
| SCHEMBL21450361 | 0.89 | RAB9A (0.65) | RAB9ANPC1TSHRKMT2AMEN1 | |
| SCHEMBL21450360 | 0.87 | RAB9A (0.83) | RAB9ANPC1TSHRKMT2AMEN1 | |
| SCHEMBL30463818 | 0.86 | MEN1 (0.66) | RAB9ANPC1TSHRKMT2AMEN1 | |
| SCHEMBL31503992 | 0.86 | RAB9A (0.72) | RAB9ANPC1TSHRKMT2AMEN1 | |
| SCHEMBL21450202 | 0.86 | RAB9A (0.61) | RAB9ANPC1TSHRKMT2AMEN1 | |
| SCHEMBL16082990 | 0.85 | MEN1 (0.85) | RAB9ANPC1TSHRKMT2AMEN1 | |
| SCHEMBL2610071 | 0.85 | MEN1 (0.85) | RAB9ANPC1TSHRKMT2AMEN1 | |
| SCHEMBL21437187 | 0.85 | MEN1 (0.63) | RAB9ANPC1TSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019193540-A1 | HETEROARYL DERIVATIVES OF FORMULA (I) AS ATF4 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-10-10 | — | — | WO | disclosed |