Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 6/20 | 0.46 |
| ▸ | ICAM1 | P05362 | 6/20 | 0.46 |
| ▸ | ITGAL | P20701 | 6/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 5/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21433985 | 1.00 | ITGB2 (0.46) | ITGB2ICAM1ITGALTRPA1FAAH | |
| SCHEMBL21434008 | 1.00 | ITGB2 (0.46) | ITGB2ICAM1ITGALTRPA1FAAH | |
| SCHEMBL21433982 | 1.00 | ITGB2 (0.46) | ITGB2ICAM1ITGALTRPA1FAAH | |
| SCHEMBL21452347 | 1.00 | ITGB2 (0.46) | ITGB2ICAM1ITGALTRPA1FAAH | |
| SCHEMBL21434129 | 0.92 | ITGB2 (0.45) | ITGB2ICAM1ITGALTRPA1SSTR1 | |
| SCHEMBL21434131 | 0.92 | ITGB2 (0.45) | ITGB2ICAM1ITGALTRPA1SSTR1 | |
| SCHEMBL21452346 | 0.92 | ITGB2 (0.45) | ITGB2ICAM1ITGALTRPA1SSTR1 | |
| SCHEMBL21433932 | 0.92 | ITGB2 (0.46) | ITGB2ICAM1ITGALTRPA1FAAH | |
| SCHEMBL21434122 | 0.92 | KMO (0.49) | ITGB2ICAM1ITGALSSTR1SSTR4 | |
| SCHEMBL21434124 | 0.92 | KMO (0.49) | ITGB2ICAM1ITGALSSTR1SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210340121-A1 | SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-11-04 | — | — | US | disclosed |
| US-11008302-B2 | Substituted pyridine and pyrimidines and their use as GluN2B receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2021-05-18 | — | — | US | disclosed |
| WO-2019193516-A2 | SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-10 | — | — | WO | disclosed |
| US-20190308950-A1 | SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190308950-A1 | SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | GRIN2B, GRIN2A, GRIN3B | ITGB2 1763/4885ICAM1 4616/4885ITGAL 1975/4885 |
| US-20210340121-A1 | SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | GRIN2B, GRIN2A, GRIN3B | ITGB2 1763/4885ICAM1 4616/4885ITGAL 1975/4885 |
| US-11008302-B2 | Substituted pyridine and pyrimidines and their use as GluN2B receptor modulators | GRIN2B, GRIN2A, GRIN3B | ITGB2 1693/4885ICAM1 4534/4885ITGAL 2140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.