SCHEMBL21453483

SCHEMBL21453483

c1ccc(-c2nc(-c3ccccc3)nc(-n3c4ccccc4c4c3ccc3c5cccc6c7ccccc7c7ccccc7c7ccccc7n(c65)c34)n2)cc1

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.32
TSHR P16473 1/20 0.32
HSD17B10 Q99714 1/20 0.32
L3MBTL1 Q9Y468 2/20 0.32
ATM Q13315 2/20 0.32
MEN1 O00255 3/20 0.32
KMT2A Q03164 3/20 0.32
MAPT P10636 2/20 0.32
ALDH1A1 P00352 2/20 0.32
HPGD P15428 2/20 0.32
GAA P10253 1/20 0.32
POLB P06746 1/20 0.32
HTT P42858 1/20 0.32
DUSP3 P51452 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21453488 0.90 KDM4E (0.32) KDM4ETSHRHSD17B10L3MBTL1ATM
SCHEMBL21453658 0.90 KDM4E (0.31) KDM4ETSHRHSD17B10
SCHEMBL20071688 0.89 KDM4E (0.32) KDM4ETSHRHSD17B10L3MBTL1ATM
SCHEMBL20071636 0.89 KDM4E (0.33) KDM4ETSHRHSD17B10L3MBTL1ATM
SCHEMBL10027515 0.88 L3MBTL1 (0.36) KDM4EL3MBTL1ATMMEN1KMT2A
SCHEMBL21453669 0.88
SCHEMBL21453481 0.88 KDM4E (0.32) KDM4ETSHRHSD17B10L3MBTL1ATM
SCHEMBL23474712 0.87 KDM4E (0.33) KDM4ETSHRHSD17B10L3MBTL1ATM
SCHEMBL21449214 0.87 KDM4E (0.33) KDM4ETSHRHSD17B10L3MBTL1ATM
SCHEMBL21454098 0.87 KDM4E (0.35) KDM4ETSHRHSD17B10L3MBTL1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11038121-B2 9 membered ring carbazole compounds Beijing Summer Sprout Technology Co., Ltd. (CN) 2021-06-15 US disclosed
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS BEIJING SUMMER SPROUT TECHNOLOGY CO., LTD (CN) 2019-10-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11038121-B2 9 membered ring carbazole compounds SLC25A21, OCIAD2, OXA1L KDM4E 3723/4885TSHR 4332/4885HSD17B10 1511/4885
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS SLC25A21, OCIAD2, OXA1L KDM4E 3723/4885TSHR 4332/4885HSD17B10 1511/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.