SCHEMBL21453487

SCHEMBL21453487

c1ccc(-c2nc(-c3ccccc3)nc(-n3c4ccccc4c4cc5c(cc43)c3cccc4c6ccccc6c6ccccc6c6ccccc6n5c43)n2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
ATM Q13315 2/20 0.33
TSHR P16473 1/20 0.33
HSD17B10 Q99714 1/20 0.33
MEN1 O00255 6/20 0.33
KMT2A Q03164 6/20 0.33
MAPT P10636 5/20 0.33
ALDH1A1 P00352 4/20 0.33
HPGD P15428 4/20 0.33
POLB P06746 2/20 0.33
GAA P10253 1/20 0.33
HTT P42858 1/20 0.33
ABCG2 Q9UNQ0 4/20 0.32
ABCB1 P08183 1/20 0.32
TP53 P04637 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
DUSP3 P51452 1/20 0.32
LMNA P02545 1/20 0.31
GLA P06280 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20068473 0.99 KDM4E (0.34) KDM4EL3MBTL1ATMTSHRHSD17B10
SCHEMBL21453486 0.96 KDM4E (0.33) KDM4EL3MBTL1ATMTSHRHSD17B10
SCHEMBL25479673 0.96 MEN1 (0.34) KDM4EL3MBTL1ATMTSHRHSD17B10
SCHEMBL20068472 0.95 KDM4E (0.33) KDM4EL3MBTL1ATMTSHRHSD17B10
SCHEMBL25479690 0.92 MEN1 (0.33) KDM4EL3MBTL1ATMTSHRHSD17B10
SCHEMBL21454099 0.91 NPY5R (0.35) KDM4EL3MBTL1ATMTSHRHSD17B10
SCHEMBL12181133 0.90 KMT2A (0.38) KDM4ETSHRHSD17B10MEN1KMT2A
SCHEMBL21965713 0.90 NPY5R (0.36) KDM4EL3MBTL1ATMTSHRHSD17B10
SCHEMBL17265064 0.90 NPY5R (0.36) KDM4EL3MBTL1ATMTSHRHSD17B10
SCHEMBL16850453 0.89 L3MBTL1 (0.42) KDM4EL3MBTL1ATMTSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11038121-B2 9 membered ring carbazole compounds Beijing Summer Sprout Technology Co., Ltd. (CN) 2021-06-15 US disclosed
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS BEIJING SUMMER SPROUT TECHNOLOGY CO., LTD (CN) 2019-10-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11038121-B2 9 membered ring carbazole compounds SLC25A21, OCIAD2, OXA1L KDM4E 3723/4885L3MBTL1 3731/4885ATM 3337/4885
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS SLC25A21, OCIAD2, OXA1L KDM4E 3723/4885L3MBTL1 3731/4885ATM 3337/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.