SCHEMBL21453663

SCHEMBL21453663

c1ccc(N2c3ccccc3[Si]3(c4ccccc42)c2ccccc2N(c2cc(-c4cccnc4)nc(-c4cccnc4)n2)c2ccccc23)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.44
CYP3A4 P08684 6/20 0.42
NPC1 O15118 3/20 0.41
RAB9A P51151 3/20 0.41
PIK3CA P42336 1/20 0.40
PIK3CB P42338 1/20 0.40
PIK3CG P48736 1/20 0.40
CYP2C9 P11712 5/20 0.39
CYP2D6 P10635 4/20 0.39
CYP2C19 P33261 4/20 0.39
CYP1A2 P05177 1/20 0.39
CHRNB2 P17787 1/20 0.37
CHRNA5 P30532 1/20 0.37
CHRNA4 P43681 1/20 0.37
CYP2E1 P05181 1/20 0.37
CYP2A6 P11509 1/20 0.37
CYP2B6 P20813 1/20 0.37
ALDH1A1 P00352 1/20 0.35
KDM6B O15054 1/20 0.35
NR1I2 O75469 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21453688 0.98 RAB9A (0.41) CYP19A1CYP3A4NPC1RAB9APIK3CA
SCHEMBL21453687 0.84 NPC1 (0.43) CYP3A4NPC1RAB9ACYP2C9CYP2D6
SCHEMBL21453327 0.84 CYP19A1 (0.44) CYP19A1CYP3A4NPC1RAB9APIK3CA
SCHEMBL21453659 0.84 CYP19A1 (0.46) CYP19A1CYP3A4NPC1RAB9ACYP2C9
SCHEMBL21453691 0.83 NPC1 (0.42) CYP3A4NPC1RAB9ACYP2C9CYP2D6
SCHEMBL21453329 0.82 RAB9A (0.41) CYP19A1CYP3A4NPC1RAB9APIK3CA
SCHEMBL20689929 0.78 HPGD (0.38) ALDH1A1HSD17B10
SCHEMBL16865038 0.77 HPGD (0.39) PIK3CAPIK3CBPIK3CGALDH1A1GRM5
SCHEMBL16865030 0.74 HPGD (0.46) CYP2C19ALDH1A1HSD17B10
SCHEMBL20689813 0.74 CYP3A4 (0.39) CYP19A1CYP3A4NPC1RAB9APIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190312210-A1 ORGANIC ELECTROLUMINESCENCE DEVICE AND POLYCYCLIC COMPOUND FOR ORGANIC ELECTROLUMINESCENCE DEVICE SAMSUNG DISPLAY CO., LTD. (KR) 2019-10-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190312210-A1 ORGANIC ELECTROLUMINESCENCE DEVICE AND POLYCYCLIC COMPOUND FOR ORGANIC ELECTROLUMINESCENCE DEVICE SLCO4C1, SLCO2A1, SLCO1A2 CYP19A1 516/4885CYP3A4 1243/4885NPC1 125/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.