SCHEMBL21453818

SCHEMBL21453818

c1ccc(-n2c3ccccc3c3ccc4c(c5cccc6c7ccccc7c7ccccc7c7ccccc7n4c65)c32)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
ATM Q13315 1/20 0.50
KMT2A Q03164 4/20 0.36
ALDH1A1 P00352 4/20 0.36
MEN1 O00255 3/20 0.36
MAPT P10636 2/20 0.36
HTT P42858 2/20 0.36
POLB P06746 2/20 0.36
HPGD P15428 1/20 0.36
MAPK1 P28482 1/20 0.36
MAPK8 P45983 2/20 0.33
IL1R1 P14778 1/20 0.33
APOBEC3G Q9HC16 1/20 0.33
MAPK9 P45984 1/20 0.33
DUSP3 P51452 1/20 0.33
PGR P06401 1/20 0.33
ALKBH5 Q6P6C2 1/20 0.33
FTO Q9C0B1 1/20 0.33
TSHR P16473 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21718203 0.97 KDM4E (0.53) KDM4EL3MBTL1ATMKMT2AALDH1A1
SCHEMBL20857786 0.94 KDM4E (0.48) KDM4EL3MBTL1ATMKMT2AALDH1A1
SCHEMBL24117548 0.92 L3MBTL1 (0.52) KDM4EL3MBTL1ATMKMT2AALDH1A1
SCHEMBL21453601 0.92 KDM4E (0.41) KDM4EL3MBTL1ATMKMT2AALDH1A1
SCHEMBL21889271 0.91 KDM4E (0.47) KDM4EL3MBTL1ATMKMT2AALDH1A1
SCHEMBL20070546 0.91 KDM4E (0.50) KDM4EL3MBTL1ATMKMT2AALDH1A1
SCHEMBL24767126 0.90 KDM4E (0.47) KDM4EL3MBTL1ATMKMT2AALDH1A1
SCHEMBL24026766 0.90 KDM4E (0.46) KDM4EL3MBTL1ATMKMT2AALDH1A1
SCHEMBL24117597 0.88 KDM4E (0.47) KDM4EL3MBTL1ATMKMT2AALDH1A1
SCHEMBL21126731 0.88 KDM4E (0.41) KDM4EL3MBTL1ATMKMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11038121-B2 9 membered ring carbazole compounds Beijing Summer Sprout Technology Co., Ltd. (CN) 2021-06-15 US disclosed
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS BEIJING SUMMER SPROUT TECHNOLOGY CO., LTD (CN) 2019-10-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11038121-B2 9 membered ring carbazole compounds SLC25A21, OCIAD2, OXA1L KDM4E 3723/4885L3MBTL1 3731/4885ATM 3337/4885
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS SLC25A21, OCIAD2, OXA1L KDM4E 3723/4885L3MBTL1 3731/4885ATM 3337/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.