Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.46 |
| ▸ | JAK3 | P52333 | 15/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 15/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2144500 | 0.99 | JAK2 (0.46) | JAK2JAK3PTK2KDM4EALDH1A1 | |
| SCHEMBL2145387 | 0.91 | PTK2 (0.46) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2145026 | 0.90 | PTK2 (0.48) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2143973 | 0.90 | JAK2 (0.51) | JAK2JAK3PTK2SLC2A1JAK1 | |
| SCHEMBL2144031 | 0.89 | JAK2 (0.44) | JAK2JAK3PTK2JAK1FLT3 | |
| SCHEMBL3303823 | 0.87 | JAK2 (0.47) | JAK2JAK3PTK2ALDH1A1JAK1 | |
| SCHEMBL3305501 | 0.87 | JAK2 (0.47) | JAK2JAK3PTK2ALDH1A1JAK1 | |
| SCHEMBL3303815 | 0.87 | JAK2 (0.47) | JAK2JAK3PTK2ALDH1A1JAK1 | |
| SCHEMBL3304372 | 0.87 | FAAH (0.44) | JAK2JAK3PTK2SIGMAR1JAK1 | |
| SCHEMBL2145289 | 0.87 | JAK2 (0.46) | JAK2JAK3PTK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | claimed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | claimed |
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | disclosed |