SCHEMBL21454737

SCHEMBL21454737

C=CCOc1cc(OCC)ccc1C1=Cc2ccc3c(c2OC1)C=CC(C)(C)O3

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ TYR P14679 1/20 0.41
▸ ODC1 P11926 1/20 0.37
▸ ACHE P22303 1/20 0.35
▸ TP53 P04637 2/20 0.34
▸ CYP3A4 P08684 2/20 0.34
▸ MAPT P10636 2/20 0.34
▸ CYP1A2 P05177 1/20 0.34
▸ HSP90AA1 P07900 1/20 0.34
▸ CYP2D6 P10635 1/20 0.34
▸ TSHR P16473 1/20 0.34
▸ CYP2C19 P33261 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ PTPN1 P18031 4/20 0.32
▸ HIF1A Q16665 3/20 0.32
▸ MGAM O43451 1/20 0.31
▸ BCHE P06276 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21454301 0.96 TYR (0.42) TYRODC1ACHETP53CYP3A4
SCHEMBL21254210 0.93 TYR (0.40) TYRODC1ACHETP53CYP3A4
SCHEMBL22145107 0.91 TYR (0.41) TYRODC1ACHETP53CYP3A4
SCHEMBL23017844 0.91 ODC1 (0.43) TYRODC1ACHETP53CYP3A4
SCHEMBL20051766 0.89 TYR (0.41) TYRODC1ACHETP53CYP3A4
SCHEMBL25453125 0.89 ODC1 (0.45) TYRODC1ACHETP53CYP3A4
SCHEMBL20051676 0.88 TYR (0.41) TYRODC1ACHETP53CYP3A4
SCHEMBL21454544 0.87 TYR (0.35) TYRODC1ACHETP53CYP3A4
SCHEMBL21447093 0.87 TYR (0.51) TYRODC1ACHETP53CYP3A4
SCHEMBL20051837 0.87 TYR (0.40) TYRODC1ACHETP53CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3524609-B1 PROCESS FOR THE PREPARATION OF 3-PHENYL-2,3,4,8,9,10-HEXAHYDROPYRANO[2,3-F]CHROMENE DERIVATIVES, OPTICAL ISOMERS THEREOF, AND INTERMEDIATES OF THE PROCESS GLACEUM INC (KR) 2021-05-26 — — EP disclosed
US-20210040106-A1 METHOD FOR SYNTHESIZING 3-PHENYL-2,8-DIHYDROPYRANO [2,3-F] CHROMENE DERIVATIVE Glaceum Inc. (KR) 2021-02-11 — — US disclosed
WO-2019194582-A1 METHOD FOR SYNTHESIZING 3-PHENYL-2,8-DIHYDROPYRANO [2,3-F] CHROMENE DERIVATIVE 주식회사 글라세움 2019-10-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210040106-A1 METHOD FOR SYNTHESIZING 3-PHENYL-2,8-DIHYDROPYRANO [2,3-F] CHROMENE DERIVATIVE HPD, CYP2J2, PAH TYR 12/4885ODC1 2294/4885ACHE 3613/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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