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Sugi Predict / Targets / HPD

HPD

4-hydroxyphenylpyruvate dioxygenase · P32754 · HPD on Sugi Atlas →

5,361 patent compounds predicted against HPD, 2,250 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL2120168 SCHEMBL2120168 0.48 11/20
SCHEMBL4285933 SCHEMBL4285933 0.45 10/20
SCHEMBL4870470 SCHEMBL4870470 0.64 9/20
SCHEMBL6205386 SCHEMBL6205386 0.58 9/20
SCHEMBL4282176 SCHEMBL4282176 0.43 9/20
SCHEMBL844506 SCHEMBL844506 0.39 9/20
SCHEMBL5837327 SCHEMBL5837327 0.54 8/20
SCHEMBL4753206 SCHEMBL4753206 0.41 8/20
SCHEMBL2120062 SCHEMBL2120062 0.50 7/20
SCHEMBL5864107 SCHEMBL5864107 0.45 7/20
SCHEMBL5324174 SCHEMBL5324174 0.45 7/20
SCHEMBL2986814 SCHEMBL2986814 0.57 6/20
SCHEMBL6601051 SCHEMBL6601051 0.56 6/20
SCHEMBL2991148 SCHEMBL2991148 0.53 6/20
SCHEMBL525607 SCHEMBL525607 0.51 6/20
SCHEMBL647866 SCHEMBL647866 0.51 6/20
SCHEMBL6121759 SCHEMBL6121759 0.44 6/20
SCHEMBL608337 SCHEMBL608337 1.00 5/20
SCHEMBL1121791 SCHEMBL1121791 0.49 5/20
SCHEMBL6054650 SCHEMBL6054650 0.48 5/20

Clinical trials — most relevant to HPD by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Implementation of Pre-emptive Geno- and Phenotyping in 5-Fluorouracil- or Capecitabine-treated Patients PHASE4UNKNOWN
Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors on Sarcopenia in Hemodialysis Patients PHASE4NOT_YET_RECRUITING
A Long-Term Safety Study of PTC923 in Participants With Phenylketonuria PHASE3ACTIVE_NOT_RECRUITING
A Study of PTC923 (CNSA-001) in Primary Tetrahydrobiopterin (BH4) Deficient Participants With Hyperphenylalaninemia PHASE1/PHASE2COMPLETED
Hyperpolarized 13C Pyruvate MRI Scan in Predicting Tumor Aggressiveness in Patients With Renal Tumors PHASE2ACTIVE_NOT_RECRUITING
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers PHASE2NOT_YET_RECRUITING
Multiple N-of-1 Trials of (Intermittent) Hypoxia Therapy in Parkinson's Disease PHASE1/PHASE2COMPLETED
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes PHASE2UNKNOWN
IDH1 (AG 120) Inhibitor in Patients With IDH1 Mutated Myelodysplastic Syndrome PHASE2ACTIVE_NOT_RECRUITING
IDH2 (AG 221) Inhibitor in Patients With IDH2 Mutated Myelodysplastic Syndrome PHASE2ACTIVE_NOT_RECRUITING
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Nitrite Infusion Studies PHASE1COMPLETED
Diclofenac Dose Response Study PHASE1RECRUITING
Nutritional Impacts of Palynziq on Patients With Phenylketonuria (PKU) nanRECRUITING
Metabolic Remodeling in Pulmonary Arterial Hypertension (PAH) nanCOMPLETED
Studies in Porphyria I: Characterization of Enzyme Defects nanUNKNOWN
Mitochondrial Function of Immune Cells in Sepsis nanCOMPLETED
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages nanCOMPLETED
Early Dietary Treated Patients With Phenylketonuria Can Achieve Normal Growth and Mental Development. nanUNKNOWN
Screening of IDH1 and IDH2 Gene Mutations in Adult Acute Myeloid Leukemia for Possible Targeted Therapy nanUNKNOWN
Comparison of Atherogenic Risk Factors and Efficacy of Nutritional Treatment Among Adult Phenylketonuria Patients nanNOT_YET_RECRUITING
Mutation Analysis of 17α-Hydroxylase nanUNKNOWN
Replacement of Vitamin D in Patients With Active Tuberculosis nanCOMPLETED
Effect of an Polyphenolic Beverage in Healthy Volunteers nanACTIVE_NOT_RECRUITING
Observational Study of Acute Intermittent Porphyria Patients nanCOMPLETED
Prevalence and Clinical Effect of IDH1/2 Mutations in Patients With Acute Myeloid Leukemia nanUNKNOWN
Ovarian Reserve and Matrix Metalloproteinases nanCOMPLETED
Prophylactic Iron and Nutrition in Preventing Infant Iron Deficiency nanCOMPLETED
Involvement of Pollutants in Atopic Dermatitis and Psoriasis nanUNKNOWN
Predictors of Outcome of Pediatric Renal Transplantation nanNOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a HPD binder may also engage these)

ProteinNameSimilarity
P49429 — 1.000 P49429 →
P32755 — 1.000 P32755 →
Q27203 — 1.000 Q27203 →
Q5BKL0 — 1.000 Q5BKL0 →
Q6CDR5 — 1.000 Q6CDR5 →
Q6TGZ5 — 1.000 Q6TGZ5 →
Q96X22 — 0.999 Q96X22 →
Q4WPV8 — 0.999 Q4WPV8 →
Q60Y65 — 0.999 Q60Y65 →
E9CWP5 — 0.997 E9CWP5 →
Q5EA20 — 0.996 Q5EA20 →
Q22633 — 0.996 Q22633 →
O42764 — 0.995 O42764 →
P0CW94 — 0.994 P0CW94 →
Q4WHU1 — 0.993 Q4WHU1 →
Q1E803 — 0.992 Q1E803 →
Q02110 — 0.991 Q02110 →
Q76NV5 — 0.989 Q76NV5 →
Q9I576 — 0.988 Q9I576 →
P23996 — 0.988 P23996 →
Q872T7 — 0.987 Q872T7 →
Q18347 — 0.987 Q18347 →
Q53586 — 0.985 Q53586 →
Q7ZXP9 — 0.983 Q7ZXP9 →
Q9ARF9 — 0.982 Q9ARF9 →
Q5ZT84 — 0.982 Q5ZT84 →
P53585 — 0.982 P53585 →
O23920 — 0.982 O23920 →
Q92448 — 0.982 Q92448 →
Q48VL3 — 0.982 Q48VL3 →