Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.77 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.60 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749069 | 0.95 | KMT2A (0.74) | MEN1KMT2ASMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL2833527 | 0.90 | KMT2A (0.68) | MEN1KMT2ASMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL4931020 | 0.88 | TP53 (0.72) | MEN1KMT2ASMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL28684197 | 0.87 | EPHX2 (0.68) | MEN1KMT2ASMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL13947386 | 0.87 | ALDH1A1 (0.66) | MEN1KMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6245709 | 0.87 | MEN1 (0.63) | MEN1KMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2833468 | 0.86 | MEN1 (0.67) | MEN1KMT2ASMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL18259860 | 0.86 | KMT2A (0.63) | MEN1KMT2ASMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL4234328 | 0.86 | MEN1 (0.63) | MEN1KMT2ASMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL4241219 | 0.86 | MEN1 (0.63) | MEN1KMT2ASMN1; SMN2HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115806503-A | Selective histone deacetylase inhibitor as well as preparation method and application thereof | 中国海洋大学 | 2023-03-17 | — | — | CN | disclosed |
| CN-115784986-A | HDAC6 inhibitor and preparation method and application thereof | 中国海洋大学 | 2023-03-14 | — | — | CN | disclosed |
| US-10870618-B2 | Histone deacetylase inhibitors and uses thereof | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2020-12-22 | — | — | US | disclosed |
| US-20190308932-A1 | HISTONE DEACETYLASE INHIBITORS AND USES THEREOF | MEDICAL UNIVERSITY OF SOUTH CAROLINA | 2019-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10870618-B2 | Histone deacetylase inhibitors and uses thereof | HDAC1, HDAC5, HDAC3 | MEN1 2599/4885KMT2A 58/4885SMN1; SMN2 2579/4885 |
| US-20190308932-A1 | HISTONE DEACETYLASE INHIBITORS AND USES THEREOF | HDAC1, HDAC5, HDAC3 | MEN1 2599/4885KMT2A 58/4885SMN1; SMN2 2579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.