Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 15/20 | 0.65 |
| ▸ | SCD | O00767 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.41 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.41 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.41 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21406155 | 0.89 | STING1 (0.81) | STING1SCD | |
| SCHEMBL21406250 | 0.89 | STING1 (0.60) | STING1SCDTUBB4ATUBBTUBA3C | |
| SCHEMBL21405853 | 0.82 | STING1 (0.62) | STING1SCDTUBB4ATUBBTUBA3C | |
| SCHEMBL22887133 | 0.82 | STING1 (0.65) | STING1SCDTUBB4ATUBBTUBA3C | |
| SCHEMBL21406026 | 0.80 | STING1 (0.67) | STING1SCDTUBB4ATUBBTUBA3C | |
| SCHEMBL21437362 | 0.80 | STING1 (0.81) | STING1SCDTUBB4ATUBBTUBA3C | |
| SCHEMBL21454832 | 0.80 | STING1 (0.81) | STING1SCDTUBB4ATUBBTUBA3C | |
| SCHEMBL28486980 | 0.79 | STING1 (0.66) | STING1SCDTUBB4ATUBBTUBA3C | |
| SCHEMBL21405913 | 0.79 | STING1 (0.62) | STING1SCDTUBB4ATUBBTUBA3C | |
| SCHEMBL25855526 | 0.79 | STING1 (0.83) | STING1SCDTUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019195063-A1 | AZA-BENZOTHIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2019-10-10 | — | — | WO | disclosed |