Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 17/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21437180 | 0.89 | STING1 (0.54) | STING1 | |
| SCHEMBL25855979 | 0.89 | STING1 (0.48) | STING1 | |
| SCHEMBL29976400 | 0.87 | STING1 (0.67) | STING1 | |
| SCHEMBL27191514 | 0.87 | STING1 (0.67) | STING1 | |
| SCHEMBL21405952 | 0.82 | STING1 (0.49) | STING1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21406152 | 0.81 | STING1 (0.48) | STING1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21406086 | 0.81 | STING1 (0.65) | STING1 | |
| SCHEMBL21406088 | 0.81 | STING1 (0.65) | STING1 | |
| SCHEMBL21406349 | 0.80 | STING1 (0.53) | STING1 | |
| SCHEMBL30666325 | 0.80 | STING1 (0.46) | STING1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019195063-A1 | AZA-BENZOTHIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2019-10-10 | — | — | WO | disclosed |