Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25895072 | 0.93 | TBXAS1 (0.37) | TBXAS1AKR1C3AKR1C2PKMSMN1; SMN2 | |
| SCHEMBL21455148 | 0.93 | TBXAS1 (0.37) | TBXAS1AKR1C3AKR1C2PKMSMN1; SMN2 | |
| SCHEMBL21455391 | 0.90 | TBXAS1 (0.36) | TBXAS1AKR1C3AKR1C2PKMSMN1; SMN2 | |
| SCHEMBL25894459 | 0.90 | TBXAS1 (0.36) | TBXAS1AKR1C3AKR1C2PKMSMN1; SMN2 | |
| SCHEMBL25097868 | 0.89 | TBXAS1 (0.36) | TBXAS1AKR1C3AKR1C2PKMSMN1; SMN2 | |
| SCHEMBL25908505 | 0.89 | TBXAS1 (0.36) | TBXAS1AKR1C3AKR1C2PKMSMN1; SMN2 | |
| SCHEMBL21455145 | 0.85 | TBXAS1 (0.36) | TBXAS1AKR1C3AKR1C2PKMSMN1; SMN2 | |
| SCHEMBL25894394 | 0.85 | TBXAS1 (0.36) | TBXAS1AKR1C3AKR1C2PKMSMN1; SMN2 | |
| SCHEMBL23656672 | 0.83 | TBXAS1 (0.36) | TBXAS1AKR1C3AKR1C2PKMSMN1; SMN2 | |
| SCHEMBL23656643 | 0.83 | TBXAS1 (0.34) | TBXAS1AKR1C3AKR1C2PKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939658-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2022-01-19 | — | — | EP | disclosed |
| WO-2019195720-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2019-10-10 | — | — | WO | disclosed |