SCHEMBL21457725

SCHEMBL21457725

CCCOC(=O)C(C#N)=Cc1cccc(Cl)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.59
PDCD1 Q15116 1/20 0.59
CD274 Q9NZQ7 1/20 0.59
ALDH1A1 P00352 7/20 0.56
KMT2A Q03164 4/20 0.56
KDM4E B2RXH2 3/20 0.56
PKM P14618 2/20 0.56
POLB P06746 1/20 0.56
LMNA P02545 2/20 0.55
DNM1 Q05193 3/20 0.54
HTT P42858 1/20 0.50
MEN1 O00255 2/20 0.48
TP53 P04637 1/20 0.47
CRHBP P24387 1/20 0.47
CRHR2 Q13324 1/20 0.47
MITF O75030 1/20 0.47
HPGD P15428 1/20 0.47
MAPK1 P28482 1/20 0.47
MDM2 Q00987 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21457722 1.00 MAPT (0.59) MAPTPDCD1CD274ALDH1A1KMT2A
SCHEMBL21457356 0.90 MAPT (0.73) MAPTPDCD1CD274ALDH1A1KMT2A
SCHEMBL4619506 0.90 MAPT (0.73) MAPTPDCD1CD274ALDH1A1KMT2A
SCHEMBL4619510 0.90 MAPT (0.73) MAPTPDCD1CD274ALDH1A1KMT2A
SCHEMBL21457596 0.87 KDM4E (0.62) MAPTPDCD1CD274ALDH1A1KMT2A
SCHEMBL21457592 0.87 KDM4E (0.62) MAPTPDCD1CD274ALDH1A1KMT2A
SCHEMBL21457342 0.86 MAPT (0.64) MAPTPDCD1CD274ALDH1A1KMT2A
SCHEMBL21457338 0.86 MAPT (0.64) MAPTPDCD1CD274ALDH1A1KMT2A
SCHEMBL21457353 0.85 MAPT (0.59) MAPTPDCD1CD274ALDH1A1KMT2A
SCHEMBL21457121 0.85 MAPT (0.59) MAPTPDCD1CD274ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3553097-B1 COPOLYMER AND OPTICAL FILM USING SAME TOSOH CORP (JP) 2022-05-04 EP disclosed
US-11225540-B2 Copolymer and optical film using same TOSOH CORPORATION (JP) 2022-01-18 US disclosed
US-20200095358-A1 COPOLYMER AND OPTICAL FILM USING SAME TOSOH CORPORATION (JP) 2020-03-26 US disclosed
EP-3553097-A1 COPOLYMER AND OPTICAL FILM USING SAME Tosoh Corporation (JP) 2019-10-16 EP disclosed