Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1609525 | 0.94 | POLB (0.51) | POLBEPHX1HTR2CSLC6A1LMNA | |
| Trifluoroacetic Acid SCHEMBL610386 | 0.91 | SLC6A1 (0.47) | POLBEPHX1SLC6A1LMNASLC6A11 | |
| Trifluoroacetic Acid SCHEMBL1437588 | 0.91 | POLB (0.61) | POLBEPHX1LMNATSHRALDH1A1 | |
| SCHEMBL2145984 | 0.89 | POLB (0.60) | POLBEPHX1SLC6A1LMNASLC6A11 | |
| SCHEMBL2145975 | 0.89 | POLB (0.60) | POLBEPHX1SLC6A1LMNASLC6A11 | |
| Trifluoroacetic Acid SCHEMBL2018902 | 0.88 | SLC6A1 (0.50) | POLBEPHX1HTR2CSLC6A1LMNA | |
| SCHEMBL2146026 | 0.87 | POLB (0.58) | POLBEPHX1LMNATSHRSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2146019 | 0.87 | POLB (0.58) | POLBEPHX1SLC6A1LMNASLC6A11 | |
| SCHEMBL2146022 | 0.87 | POLB (0.58) | POLBEPHX1LMNATSHRSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2146630 | 0.85 | POLB (0.56) | POLBEPHX1LMNATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |