Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21004319 | 0.89 | POLB (0.50) | LMNAKMT2APOLBSMN1; SMN2TP53 | |
| SCHEMBL18745372 | 0.84 | BCHE (0.41) | LMNAKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL18626574 | 0.84 | BCHE (0.41) | LMNAKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL24411683 | 0.82 | ACKR3 (0.38) | LMNAKMT2APOLBSMN1; SMN2TP53 | |
| SCHEMBL26138797 | 0.81 | KMT2A (0.39) | LMNAKMT2APOLBSMN1; SMN2TP53 | |
| SCHEMBL18745367 | 0.81 | ALDH1A1 (0.43) | LMNAKMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL24411712 | 0.80 | POLB (0.44) | LMNAKMT2APOLBSMN1; SMN2TP53 | |
| SCHEMBL26254874 | 0.80 | KMT2A (0.49) | LMNAKMT2APOLBSMN1; SMN2TP53 | |
| SCHEMBL24411692 | 0.80 | KMT2A (0.41) | LMNAKMT2APOLBSMN1; SMN2TP53 | |
| SCHEMBL18745375 | 0.79 | BCHE (0.47) | KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |