SCHEMBL21462444

SCHEMBL21462444

COc1ccc2nc(-c3cnc(N4CCC(CCO)CC4)nc3)sc2c1

nearest known ligand 0.51

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
APP P05067 12/20 0.51
MAPT P10636 3/20 0.46
LMNA P02545 1/20 0.45
TP53 P04637 1/20 0.45
GLA P06280 1/20 0.44
GAA P10253 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23327788 0.89 APP (0.52) APPMAPTGLAGAA
SCHEMBL21462584 0.87 APP (0.46) APPMAPTGLAGAA
SCHEMBL21462403 0.86 APP (0.51) APPMAPTTP53
SCHEMBL21462572 0.83 APP (0.46) APP
SCHEMBL21462795 0.82 PCSK9 (0.46) MAPTTP53GAA
SCHEMBL21462536 0.82 MAPT (0.42) APPMAPT
SCHEMBL21462433 0.82 APP (0.50) APPMAPTLMNATP53GAA
SCHEMBL23263904 0.81 APP (0.53) APPMAPTLMNATP53GLA
SCHEMBL2055233 0.81 ILK (0.59) APPGLAGAA
SCHEMBL21462494 0.79 APP (0.52) APPMAPTLMNATP53GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12636385-B2 Selective ligands for tau aggregates SENTONIX, INC. (US) 2026-05-26 US claimed
US-20210138092-A1 SELECTIVE LIGANDS FOR TAU AGGREGATES CBD SOLUTIONS AB (SE) 2021-05-13 US claimed
EP-3774771-A1 SELECTIVE LIGANDS FOR TAU AGGREGATES Karin&Sten Mortstedt CBD Solutions AB (SE) 2021-02-17 EP claimed
WO-2019197502-A1 SELECTIVE LIGANDS FOR TAU AGGREGATES KARIN & STEN MORTSTEDT CBD SOLUTIONS AB (SE) 2019-10-17 WO claimed
US-12636385-B2 Selective ligands for tau aggregates SENTONIX, INC. (US) 2026-05-26 US disclosed
US-20210138092-A1 SELECTIVE LIGANDS FOR TAU AGGREGATES CBD SOLUTIONS AB (SE) 2021-05-13 US disclosed
US-20210138092-A1 SELECTIVE LIGANDS FOR TAU AGGREGATES CBD SOLUTIONS AB (SE) 2021-05-13 US disclosed
EP-3774771-A1 SELECTIVE LIGANDS FOR TAU AGGREGATES Karin&Sten Mortstedt CBD Solutions AB (SE) 2021-02-17 EP disclosed
WO-2019197502-A1 SELECTIVE LIGANDS FOR TAU AGGREGATES KARIN & STEN MORTSTEDT CBD SOLUTIONS AB (SE) 2019-10-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210138092-A1 SELECTIVE LIGANDS FOR TAU AGGREGATES MAPT, PSEN1, PSEN2 APP 12/4885MAPT 1/4885LMNA 2633/4885
US-12636385-B2 Selective ligands for tau aggregates MAPT, PSEN2, PSEN1 APP 36/4885MAPT 1/4885LMNA 749/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.