SCHEMBL2146395

SCHEMBL2146395

O=C(C1CCNC1)N1CCC(F)(F)CC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.46
CHRNA3 P32297 2/20 0.46
CHRNA4 P43681 2/20 0.46
CHRNB3 Q05901 1/20 0.46
CHRNA6 Q15825 1/20 0.46
PLAT P00750 2/20 0.40
ITGB3 P05106 3/20 0.39
ITGA2B P08514 3/20 0.39
TLR9 Q9NR96 3/20 0.38
TLR8 Q9NR97 3/20 0.38
TLR7 Q9NYK1 3/20 0.38
DPP4 P27487 1/20 0.37
FAP Q12884 1/20 0.37
DPP7 Q9UHL4 1/20 0.37
ALDH1A1 P00352 2/20 0.36
TSHR P16473 2/20 0.36
HPGD P15428 1/20 0.36
SFRP1 Q8N474 2/20 0.36
CHRNB4 P30926 1/20 0.36
CHRNA7 P36544 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2145895 0.98 CHRNB2 (0.44) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL2146327 0.90 DPP4 (0.46) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL16207607 0.90 CHRNB2 (0.58) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
Hydrochloric Acid SCHEMBL2146316 0.89 DPP4 (0.45) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
Hydrochloric Acid SCHEMBL29644789 0.84 CHRNB2 (0.41) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL2148562 0.81 GRM5 (0.44) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL2146552 0.81 GRM5 (0.44) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL2673313 0.80 CHRNB2 (0.53) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL4546710 0.80 CHRNB2 (0.53) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL2673319 0.80 CHRNB2 (0.53) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011088045-A1 AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE AMBIT BIOSCIENCES CORPORATION (US) 2011-07-21 WO disclosed