Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 7/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MGAM | O43451 | 1/20 | 0.49 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SI | P14410 | 1/20 | 0.49 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21008396 | 0.85 | APAF1 (0.56) | APAF1POLBRAB9ANPC1LMNA | |
| SCHEMBL21008394 | 0.85 | APAF1 (0.56) | APAF1POLBRAB9ANPC1LMNA | |
| SCHEMBL21008395 | 0.85 | APAF1 (0.56) | APAF1POLBRAB9ANPC1LMNA | |
| SCHEMBL13729890 | 0.81 | APAF1 (0.78) | APAF1POLBRAB9ANPC1LMNA | |
| SCHEMBL17755748 | 0.81 | MME (0.47) | APAF1POLBRAB9ANPC1LMNA | |
| SCHEMBL17755745 | 0.81 | MME (0.47) | APAF1POLBRAB9ANPC1LMNA | |
| SCHEMBL23774830 | 0.80 | APAF1 (0.76) | APAF1POLBRAB9ANPC1LMNA | |
| SCHEMBL28603963 | 0.77 | HSD17B10 (0.60) | APAF1POLBRAB9ANPC1LMNA | |
| SCHEMBL22225773 | 0.77 | MME (0.51) | APAF1POLBRAB9ANPC1LMNA | |
| SCHEMBL21466973 | 0.77 | MME (0.51) | APAF1POLBRAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11273147-B2 | Selective androgen receptor degrader (SARD) ligands and methods of use thereof | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2022-03-15 | — | — | US | disclosed |
| US-20210161864-A1 | SELECTIVE ANDROGEN RECEPTOR DEGRADER (SARD) LIGANDS AND METHODS OF USE | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2021-06-03 | — | — | US | disclosed |
| US-20200222365-A1 | SELECTIVE ANDROGEN RECEPTOR DEGRADER (SARD) LIGANDS AND METHODS OF USE THEREOF | Oncternal Therapeutics, Inc. (US) | 2020-07-16 | — | — | US | disclosed |
| US-10441570-B2 | Selective androgen receptor degrader (SARD) Ligands and methods of use thereof | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2019-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210161864-A1 | SELECTIVE ANDROGEN RECEPTOR DEGRADER (SARD) LIGANDS AND METHODS OF USE | AR, BRCA1, FSHR | APAF1 1153/4885POLB 1875/4885RAB9A 4305/4885 |
| US-10441570-B2 | Selective androgen receptor degrader (SARD) Ligands and methods of use thereof | AR, AHR, BRDT | APAF1 1011/4885POLB 1375/4885RAB9A 4609/4885 |
| US-11273147-B2 | Selective androgen receptor degrader (SARD) ligands and methods of use thereof | AR, AHR, BRDT | APAF1 1011/4885POLB 1375/4885RAB9A 4609/4885 |
| US-20200222365-A1 | SELECTIVE ANDROGEN RECEPTOR DEGRADER (SARD) LIGANDS AND METHODS OF USE THEREOF | AR, AHR, BRDT | APAF1 1011/4885POLB 1375/4885RAB9A 4609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.