APAF1

Apoptotic protease-activating factor 1 · O14727 · APAF1 on Sugi Atlas →

92,845 patent compounds predicted against APAF1, 59,653 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
2-Chloro-3-Morpholino-1,4-Naphthoquinone (SCHEMBL197256)	0.58	7/20
SCHEMBL150458	0.56	6/20
SCHEMBL175459	0.46	6/20
SCHEMBL155510	0.45	6/20
SCHEMBL155511	0.45	6/20
9,10-Phenanthrenequinone (SCHEMBL43050)	1.00	4/20
SCHEMBL43327	0.63	4/20
SCHEMBL29530	0.55	4/20
SCHEMBL123559	0.52	4/20
Benzethonium (SCHEMBL21713)	1.00	3/20
Benzethonium (SCHEMBL122985)	1.00	3/20
Methylbenzethonium (SCHEMBL136062)	1.00	3/20
Anthraquinone (SCHEMBL14943)	0.79	3/20
Hydrochloric Acid (SCHEMBL120301)	0.78	3/20
Benzethonium (SCHEMBL139530)	0.68	3/20
SCHEMBL56824	0.52	3/20
SCHEMBL18844	0.52	3/20
SCHEMBL79475	0.52	3/20
SCHEMBL88058	0.52	3/20
SCHEMBL143100	0.52	3/20

Clinical trials — most relevant to APAF1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer	PHASE4	UNKNOWN
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit	PHASE2/PHASE3	WITHDRAWN
Prostate Radiation Therapy or Short-Term Androgen Deprivation Therapy and Pelvic Lymph Node Radiation Therapy With or Without Prostate Radiation Therapy in Treating Patients With a Rising Prostate Specific Antigen (PSA) After Surgery for Prostate Cancer	PHASE3	UNKNOWN
Disulfiram in Rheumatoid Arthritis	PHASE2	NOT_YET_RECRUITING
Safety, Tolerability, and Treatment Effect of Belnacasan in Patients With COVID-19	PHASE2	COMPLETED
Acetylsalicylic Acid and Eflornithine in Treating Patients at High Risk for Colorectal Cancer	PHASE2	COMPLETED
Decitabine and Venetoclax Treatment as Maintenance Therapy in Patients Post Allograft Stem Cell Transplant	PHASE1/PHASE2	RECRUITING
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure	nan	RECRUITING
Impact of CASP3 Gene in Chemoresistance	nan	NOT_YET_RECRUITING
Role of Serum ADAM 17 (A Disintegrin And Metalloprotease 17) and Caspase 3 in Patients With Chronic Kidney Disease	nan	NOT_YET_RECRUITING
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients	nan	UNKNOWN
Effects of Capacitive Radiofrequency at the Dermis and Adipose Tissue	nan	COMPLETED
Study of Lipolysis of Visceral Reserve Fat Using Tecar Therapy.	nan	COMPLETED
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases	nan	UNKNOWN
Serum Caspase 3, Annexin a2 and Soluble Fas Levels and Endometriosis	nan	COMPLETED
Caspase-1 Activity, IL-1beta, and IL-18 in Patients With FMF	nan	NOT_YET_RECRUITING
Skeletal Muscle Apoptosis and Physical Performance; Oxidative RNA/DNA Damage and Repair in Aged Human Muscle	nan	COMPLETED
Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis)	nan	COMPLETED
Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma	nan	UNKNOWN
Evaluation of Inflammasome Gene Polymorphisms in Periodontitis Patients	nan	UNKNOWN
The Mechanisms and Significances of Synergistic Effects of Mycophenolic Acid and LPS on IL-1β Secretion by Mononuclear	nan	UNKNOWN
High Dose Omega-3 Fatty Acids in the Treatment of Sport Related Concussions	nan	COMPLETED
Role of SIRT1 in Regulation of Epithelial-to-mesenchymal Transition in Breast Cancer Lymph Nodes Metastasis	nan	UNKNOWN
Comparison of ICSI Outcomes in Cycles Using Testicular and Ejaculate Sperm From Couples With High SDF	nan	COMPLETED
Genetic Determinants of Sudden Cardiac Death	nan	COMPLETED
Gluten-related Disorders in Familial Mediterranean Fever Patients	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a APAF1 binder may also engage these)

Protein	Name	Similarity
O88879	—	1.000	O88879 →
Q9EPV5	—	1.000	Q9EPV5 →
Q9I9H8	—	0.988	Q9I9H8 →
F1M649	—	0.983	F1M649 →
P0CI65	—	0.982	P0CI65 →
Q6P5U7	—	0.982	Q6P5U7 →
F1MHT9	—	0.982	F1MHT9 →
Q9NPP4	—	0.981	Q9NPP4 →
DAPK1	Death-associated protein kinase 1	0.981	landscape →
Q80YE7	—	0.981	Q80YE7 →
Q6AZT7	—	0.981	Q6AZT7 →
Q3UP24	—	0.981	Q3UP24 →
PRMT9	Protein arginine N-methyltransferase 9	0.981	landscape →
Q8BTI9	—	0.981	Q8BTI9 →
Q9GLV6	—	0.981	Q9GLV6 →
Q6DFC6	—	0.981	Q6DFC6 →
Q9ULI1	—	0.981	Q9ULI1 →
Q80ZJ6	—	0.981	Q80ZJ6 →
Q5RF63	—	0.980	Q5RF63 →
A0JM23	—	0.980	A0JM23 →
Q3UQV5	—	0.980	Q3UQV5 →
Q7ZVA0	—	0.980	Q7ZVA0 →
Q8LEV3	—	0.980	Q8LEV3 →
Q5K651	—	0.979	Q5K651 →
RECQL	ATP-dependent DNA helicase Q1	0.979	landscape →
B1H285	—	0.979	B1H285 →
Q8W117	—	0.979	Q8W117 →
Q008S8	—	0.979	Q008S8 →
Q6Q899	—	0.979	Q6Q899 →
Q6AYJ1	—	0.979	Q6AYJ1 →