Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 4/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22472954 | 0.82 | ALDH1A1 (0.58) | ALDH1A1CYP1A2KMT2ANPC1RAB9A | |
| SCHEMBL21364632 | 0.80 | ALDH1A1 (0.51) | ALDH1A1CYP1A2KMT2ARAB9ACYP3A4 | |
| SCHEMBL21499257 | 0.79 | CYP1A2 (0.39) | ALDH1A1CYP1A2NQO2KMT2ANPSR1 | |
| SCHEMBL22594086 | 0.79 | CYP1A2 (0.39) | ALDH1A1CYP1A2NQO2KMT2ANPSR1 | |
| SCHEMBL30178501 | 0.75 | ALDH1A1 (0.56) | ALDH1A1CYP1A2HTR1AADRA1DADRA1A | |
| SCHEMBL27449 | 0.75 | ALDH1A1 (0.56) | ALDH1A1CYP1A2HTR1AADRA1DADRA1A | |
| SCHEMBL19772862 | 0.72 | CYP1A2 (0.44) | ALDH1A1CYP1A2NPC1RAB9ACYP3A4 | |
| SCHEMBL27022434 | 0.72 | ALDH1A1 (0.56) | ALDH1A1CYP1A2NPC1RAB9APOLB | |
| SCHEMBL19494307 | 0.72 | NQO2 (0.43) | ALDH1A1CYP1A2NQO2NPC1RAB9A | |
| Methylene Chloride SCHEMBL27458429 | 0.71 | ALDH1A1 (0.48) | ALDH1A1CYP1A2HTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10442783-B2 | 2,3-disubstituted chromen-4-one compounds as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2019-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10442783-B2 | 2,3-disubstituted chromen-4-one compounds as modulators of protein kinases | PIK3CB, PIK3CD, PDPK1 | ALDH1A1 4410/4885CYP1A2 3691/4885HTR1A 2032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.