Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 11/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.39 |
| ▸ | PRKDC | P78527 | 11/20 | 0.39 |
| ▸ | EGFR | P00533 | 10/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.39 |
| ▸ | ABL1 | P00519 | 9/20 | 0.39 |
| ▸ | HCK | P08631 | 9/20 | 0.39 |
| ▸ | SRC | P12931 | 9/20 | 0.39 |
| ▸ | MTOR | P42345 | 9/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 9/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.39 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17970622 | 0.90 | KDR (0.44) | TGFBR1KCNH2KDRPIK3CDPIK3CA | |
| SCHEMBL21467105 | 0.82 | JAK2 (0.46) | KDRPIK3CDPIK3CAPIK3CGPRKDC | |
| SCHEMBL129822 | 0.78 | PIK3CD (0.63) | TGFBR1KCNH2KDRPIK3CDPIK3CA | |
| SCHEMBL17970655 | 0.78 | KDR (0.51) | TGFBR1KDRPIK3CDPIK3CAPIK3CG | |
| SCHEMBL3782102 | 0.76 | PIK3CD (0.57) | KDRPIK3CDPIK3CAPIK3CGPRKDC | |
| SCHEMBL21467106 | 0.76 | PIK3CD (0.39) | TGFBR1KDRPIK3CDPIK3CAPIK3CG | |
| SCHEMBL27753701 | 0.75 | SRC (0.67) | KDRPIK3CDPIK3CAPIK3CGPRKDC | |
| SCHEMBL22275989 | 0.74 | MAP4K4 (0.49) | PIK3CDPIK3CAPIK3CGPRKDCPIK3CB | |
| SCHEMBL30386858 | 0.74 | PIK3CD (0.61) | KDRPIK3CDPIK3CAPIK3CGPRKDC | |
| SCHEMBL23917483 | 0.73 | PIK3CD (0.60) | KCNH2KDRPIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858907-B2 | Kinase modulators | RHIZEN PHARMACEUTICALS AG (CH) | 2024-01-02 | — | — | US | disclosed |
| US-10442783-B2 | 2,3-disubstituted chromen-4-one compounds as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2019-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10442783-B2 | 2,3-disubstituted chromen-4-one compounds as modulators of protein kinases | PIK3CB, PIK3CD, PDPK1 | TGFBR1 2783/4885KCNH2 4148/4885KDR 866/4885 |
| US-11858907-B2 | Kinase modulators | RPS6KA1, RPS6KA2, PRKAR2A | TGFBR1 939/4885KCNH2 3781/4885KDR 823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.