Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 10/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | USP2 | O75604 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.35 |
| ▸ | ERN1 | O75460 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2146768 | 1.00 | CYP1A2 (0.36) | CYP1A2CYP2C19ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL2146365 | 0.90 | ALOX15 (0.38) | CYP1A2CYP2C19ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL2146361 | 0.90 | ALOX15 (0.38) | CYP1A2CYP2C19ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL2285279 | 0.89 | ERN1 (0.43) | CYP1A2CYP2C19ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL2286335 | 0.87 | CYP1A2 (0.36) | CYP1A2CYP2C19ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL2146496 | 0.87 | CYP1A2 (0.36) | CYP1A2CYP2C19ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL2159526 | 0.87 | CYP1A2 (0.37) | CYP1A2CYP2C19ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL2159532 | 0.87 | CYP1A2 (0.37) | CYP1A2CYP2C19ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL2147668 | 0.85 | ERN1 (0.40) | CYP1A2CYP2C19ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL2147661 | 0.85 | ERN1 (0.40) | CYP1A2CYP2C19ALOX15HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110201555-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-08-18 | — | — | US | claimed |
| EP-2346824-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-07-27 | — | — | EP | claimed |
| WO-2010031852-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2010-03-25 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201555-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | ESR1, ESRRA, GPER1 | CYP1A2 1232/4885CYP2C19 1258/4885ALOX15 2595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.