Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2146788 | 1.00 | LMNA (0.41) | LMNAPOLBALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL2146779 | 1.00 | LMNA (0.41) | LMNAPOLBALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL2146793 | 1.00 | LMNA (0.41) | LMNAPOLBALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL2008316 | 0.78 | LMNA (0.42) | LMNAPOLBALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL2008314 | 0.78 | LMNA (0.42) | LMNAPOLBALDH1A1SMN1; SMN2USP2 | |
| Hydrochloric Acid SCHEMBL78386 | 0.68 | LMNA (0.40) | LMNAPOLBALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL12533448 | 0.68 | LMNA (0.40) | LMNAPOLBALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL15269924 | 0.67 | LMNA (0.46) | LMNAPOLBALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL18609254 | 0.67 | LMNA (0.46) | LMNAPOLBALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL7195828 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |