Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 11/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA3 | P07451 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15882287 | 0.87 | NOTUM (0.55) | NOTUMLMNASMN1; SMN2PKMKMT2A | |
| SCHEMBL29707987 | 0.87 | NOTUM (0.55) | NOTUMLMNASMN1; SMN2PKMKMT2A | |
| SCHEMBL14058949 | 0.84 | ACLY (0.53) | NOTUMSMN1; SMN2KMT2AALDH1A1TRIM24 | |
| SCHEMBL29707960 | 0.84 | NOTUM (0.51) | NOTUMLMNAPKMKMT2ACYP11B2 | |
| SCHEMBL17545345 | 0.84 | NPSR1 (0.57) | NOTUMLMNAKMT2AALDH1A1 | |
| SCHEMBL15882573 | 0.84 | NOTUM (0.51) | NOTUMLMNAPKMKMT2ACYP11B2 | |
| SCHEMBL32673770 | 0.83 | NOTUM (0.54) | NOTUMLMNASMN1; SMN2CYP11B2CA12 | |
| SCHEMBL7140297 | 0.83 | NOTUM (0.54) | NOTUMLMNASMN1; SMN2CYP11B2CA12 | |
| SCHEMBL17545082 | 0.83 | NPSR1 (0.59) | NOTUMLMNASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL7610677 | 0.82 | NOTUM (0.49) | NOTUMLMNASMN1; SMN2CYP11B2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180312-B1 | INDOLINE SULFONAMIDE INHIBITORS OF DAPE AND NDM-1 AND USE OF THE SAME | UNIV LOYOLA CHICAGO (US) | 2019-10-16 | — | — | EP | disclosed |