Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | BCL9 | O00512 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
| ▸ | DGKA | P23743 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10704366 | 1.00 | KMT2A (0.58) | KMT2ASMN1; SMN2THRBALOX15NPC1 | |
| SCHEMBL11456829 | 0.93 | KMT2A (0.50) | KMT2ASMN1; SMN2THRBALOX15NPC1 | |
| SCHEMBL38661498 | 0.90 | KMT2A (0.68) | KMT2ASMN1; SMN2ALOX15NPC1RAB9A | |
| SCHEMBL5696715 | 0.90 | KMT2A (0.68) | KMT2ASMN1; SMN2ALOX15NPC1RAB9A | |
| SCHEMBL15549028 | 0.90 | KMT2A (0.68) | KMT2ASMN1; SMN2ALOX15NPC1RAB9A | |
| SCHEMBL5696854 | 0.90 | KMT2A (0.68) | KMT2ASMN1; SMN2ALOX15NPC1RAB9A | |
| SCHEMBL5696798 | 0.90 | KMT2A (0.68) | KMT2ASMN1; SMN2ALOX15NPC1RAB9A | |
| SCHEMBL15987877 | 0.89 | KMT2A (0.59) | KMT2ASMN1; SMN2THRBALOX15NPC1 | |
| SCHEMBL28371002 | 0.89 | KMT2A (0.59) | KMT2ASMN1; SMN2THRBALOX15NPC1 | |
| SCHEMBL28366896 | 0.89 | KMT2A (0.59) | KMT2ASMN1; SMN2THRBALOX15NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019200367-A9 | BRUSH PRODRUGS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2019-12-19 | — | — | WO | disclosed |
| WO-2019200367-A1 | BRUSH PRODRUGS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2019-10-17 | — | — | WO | disclosed |