Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 14/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.37 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23326985 | 0.89 | KIT (0.42) | KITAURKBPDGFRBKDRPRMT5 | |
| SCHEMBL21470707 | 0.86 | TYRO3 (0.44) | KITAURKBPDGFRBKDRPRMT5 | |
| SCHEMBL21470706 | 0.86 | NR1H2 (0.42) | KITAURKBPDGFRBKDR | |
| SCHEMBL21470533 | 0.78 | KIT (0.44) | KITKDRGSK3BDYRK1A | |
| SCHEMBL21470715 | 0.78 | KIT (0.45) | KIT | |
| SCHEMBL21470718 | 0.78 | KIT (0.40) | KIT | |
| SCHEMBL21470842 | 0.78 | KIT (0.43) | KITKDRGSK3BDYRK1A | |
| SCHEMBL23353703 | 0.74 | ABL1 (0.43) | KITPDGFRBKDR | |
| SCHEMBL21470491 | 0.72 | DRD1 (0.34) | WNT1GSK3BDYRK1A | |
| SCHEMBL21470816 | 0.71 | DRD1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019200120-A1 | DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | LYCERA CORPORATION (US) | 2019-10-17 | — | — | WO | disclosed |