Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.56 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.56 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15287198 | 0.81 | TNKS (0.53) | TNKSTNKS2GAAALDH1A1KDM4E | |
| SCHEMBL18352916 | 0.80 | TNKS (0.68) | TNKSTNKS2BRD9KDM4E | |
| SCHEMBL4304287 | 0.79 | GAA (0.49) | GAAALDH1A1KDM4EGLAL3MBTL1 | |
| SCHEMBL14716607 | 0.77 | GAA (0.47) | GAAALDH1A1KDM4EGLAL3MBTL1 | |
| SCHEMBL16862958 | 0.75 | TNKS (0.73) | TNKSTNKS2 | |
| SCHEMBL16862944 | 0.73 | TNKS (0.62) | TNKSTNKS2GAAALDH1A1KDM4E | |
| SCHEMBL16862949 | 0.72 | TNKS (0.69) | TNKSTNKS2GAA | |
| SCHEMBL16863112 | 0.72 | TNKS (1.00) | TNKSTNKS2 | |
| SCHEMBL8018250 | 0.72 | TNKS (0.46) | TNKSTNKS2GAAALDH1A1KDM4E | |
| SCHEMBL14725992 | 0.72 | ALDH1A3 (0.54) | BRD9GAAALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3087076-B1 | IMIDAZOPYRAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-09-27 | — | — | EP | disclosed |
| US-9718826-B2 | Imidazopyrazinone derivatives | MERCK PATENT GMBH (DE) | 2017-08-01 | — | — | US | disclosed |
| US-9718826-B2 | Imidazopyrazinone derivatives | MERCK PATENT GMBH (DE) | 2017-08-01 | — | — | US | disclosed |
| EP-2526102-B1 | Inhibitors of PI3 kinase | FUNDACIÓN CENTRO NAC DE INVESTIG ONCOLÓGICAS CARLOS III (ES) | 2017-03-08 | — | — | EP | disclosed |
| US-20170002010-A1 | IMIDAZOPYRAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-01-05 | — | — | US | disclosed |
| US-20170002010-A1 | IMIDAZOPYRAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-01-05 | — | — | US | disclosed |
| US-9073927-B2 | Inhibitors of PI3 kinase | FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III (ES) | 2015-07-07 | — | — | US | disclosed |
| US-9073927-B2 | Inhibitors of PI3 kinase | FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III (ES) | 2015-07-07 | — | — | US | disclosed |
| US-9073927-B2 | Inhibitors of PI3 kinase | FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III (ES) | 2015-07-07 | — | — | US | disclosed |
| WO-2015096884-A1 | IMIDAZOPYRAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-07-02 | — | — | WO | disclosed |
| US-20130053371-A1 | INHIBITORS OF PI3 KINASE | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2013-02-28 | — | — | US | disclosed |
| US-20130053371-A1 | INHIBITORS OF PI3 KINASE | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2013-02-28 | — | — | US | disclosed |
| US-20130053371-A1 | INHIBITORS OF PI3 KINASE | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2013-02-28 | — | — | US | disclosed |
| WO-2011089400-A1 | INHIBITORS OF PI3 KINASE | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2011-07-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053371-A1 | INHIBITORS OF PI3 KINASE | PIK3CA, MTOR, PIK3C2A | TNKS 1554/4885TNKS2 1467/4885BRD9 1348/4885 |
| US-20170002010-A1 | IMIDAZOPYRAZINONE DERIVATIVES | IRAK1, IRAK3, TNKS | TNKS 3/4885TNKS2 14/4885BRD9 3133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.