Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.35 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.35 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2732777 | 0.91 | MTOR (0.45) | MTORRPTORMLST8MAP3K12DGAT1 | |
| SCHEMBL2706919 | 0.91 | MTOR (0.35) | MTORRPTORMLST8MAP3K12DGAT1 | |
| SCHEMBL2147933 | 0.91 | RET (0.34) | MTORRPTORMLST8GPR119PIK3CA | |
| SCHEMBL12461414 | 0.91 | RET (0.34) | MTORRPTORMLST8GPR119PIK3CA | |
| SCHEMBL14298329 | 0.91 | RET (0.34) | MTORRPTORMLST8GPR119PIK3CA | |
| SCHEMBL30766 | 0.91 | RET (0.34) | MTORRPTORMLST8GPR119PIK3CA | |
| SCHEMBL17399229 | 0.91 | RET (0.34) | MTORRPTORMLST8GPR119PIK3CA | |
| SCHEMBL2147571 | 0.91 | RET (0.34) | MTORRPTORMLST8GPR119PIK3CA | |
| SCHEMBL14316244 | 0.91 | RET (0.34) | MTORRPTORMLST8GPR119PIK3CA | |
| SCHEMBL2147763 | 0.90 | MTOR (0.34) | MTORRPTORMLST8PIK3CADGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011090935-A1 | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-28 | — | — | WO | disclosed |