SCHEMBL21471528

SCHEMBL21471528

Brc1nc(I)cn2ccnc12

nearest known ligand 0.45

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.44
HTR2C P28335 1/20 0.40
NUDT1 P36639 1/20 0.36
TNKS O95271 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12777856 0.85 L3MBTL1 (0.41) L3MBTL1HTR2CNUDT1
SCHEMBL12778116 0.80 L3MBTL1 (0.39) L3MBTL1HTR2CNUDT1
SCHEMBL103894 0.80 HTR2C (0.53) L3MBTL1HTR2CNUDT1TNKS
SCHEMBL24387465 0.77 L3MBTL1 (0.37) L3MBTL1HTR2CNUDT1TNKS
SCHEMBL11261436 0.77 L3MBTL1 (0.44) L3MBTL1HTR2CNUDT1TNKS
SCHEMBL14538474 0.77 L3MBTL1 (0.44) L3MBTL1HTR2CNUDT1TNKS
SCHEMBL18248770 0.77 L3MBTL1 (0.53) L3MBTL1HTR2CNUDT1TNKS
SCHEMBL25987094 0.77 L3MBTL1 (0.41) L3MBTL1HTR2CNUDT1
SCHEMBL12778120 0.73 L3MBTL1 (0.41) L3MBTL1HTR2CNUDT1TNKS
SCHEMBL12777922 0.73 L3MBTL1 (0.33) L3MBTL1HTR2CNUDT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3553065-A1 HETEROCYCLIC COMPOUND AS SYK INHIBITOR AND/OR SYK-HDAC DUAL INHIBITOR Hangzhou Innogate Pharma Co., Ltd. (CN) 2019-10-16 EP disclosed