Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20128802 | 0.87 | HRH3 (0.34) | HRH3 | |
| SCHEMBL20317416 | 0.81 | HRH3 (0.31) | HRH3CYP4F2CYP4A11 | |
| SCHEMBL24788127 | 0.80 | GPR119 (0.32) | CYP4F2CYP4A11 | |
| SCHEMBL18592213 | 0.79 | GBA2 (0.38) | — | |
| SCHEMBL21673514 | 0.78 | MCHR1 (0.32) | CYP4F2CYP4A11 | |
| SCHEMBL20231173 | 0.75 | HRH3 (0.39) | HRH3 | |
| SCHEMBL20128779 | 0.75 | GRIN1 (0.32) | — | |
| SCHEMBL21664798 | 0.73 | GPR119 (0.34) | CYP4F2CYP4A11 | |
| SCHEMBL24762272 | 0.73 | GPR119 (0.34) | CYP4F2CYP4A11 | |
| SCHEMBL21664489 | 0.73 | GBA2 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11161841-B2 | Modulators of proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2021-11-02 | — | — | US | disclosed |
| US-20190315732-A1 | MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2019-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315732-A1 | MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE | MDM2, CRBN, VHL | HRH3 4061/4885CYP4F2 4388/4885CYP4A11 4782/4885 |
| US-11161841-B2 | Modulators of proteolysis and associated methods of use | MDM2, CRBN, VHL | HRH3 4061/4885CYP4F2 4388/4885CYP4A11 4782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.