Sugi Predict

Sugi Predict / Compounds / SCHEMBL21472001

SCHEMBL21472001

SCHEMBL21472001

CC(C)(C)OC(=O)N1C[C@H](OCCOCCOC2CCCCO2)C[C@H]1CO[Si](C)(C)C(C)(C)C

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ ABCB1 P08183 1/20 0.32
▸ MEN1 O00255 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ ATM Q13315 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21471989 1.00 ABCB1 (0.32) ABCB1MEN1KMT2AALDH1A1ATM
SCHEMBL21471791 1.00 ABCB1 (0.32) ABCB1MEN1KMT2AALDH1A1ATM
SCHEMBL21458411 0.91 MEN1 (0.34) MEN1KMT2A
SCHEMBL21458386 0.91 MEN1 (0.34) MEN1KMT2A
SCHEMBL21458527 0.91 MEN1 (0.34) MEN1KMT2A
SCHEMBL21472054 0.86 NR1H2 (0.34) ABCB1MEN1KMT2AALDH1A1ATM
SCHEMBL21471790 0.86 NR1H2 (0.34) ABCB1MEN1KMT2AALDH1A1ATM
SCHEMBL21472362 0.86 NR1H2 (0.34) ABCB1MEN1KMT2AALDH1A1ATM
SCHEMBL30732601 0.82 ABCB1 (0.35) ABCB1ALDH1A1
SCHEMBL30530778 0.80 NR1H2 (0.37) ABCB1MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12552783-B2 Modulators of proteolysis and associated methods of use ARVINAS OPERATIONS, INC. (US) 2026-02-17 — — US disclosed
EP-4132655-A1 COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF KRAS Arvinas Operations, Inc. (US) 2023-02-15 — — EP disclosed
US-20220402907-A1 MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE YALE UNIVERSITY 2022-12-22 — — US disclosed
US-20220402907-A1 MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE YALE UNIVERSITY 2022-12-22 — — US disclosed
US-20220370416-A1 COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF KRAS YALE UNIVERSITY 2022-11-24 — — US disclosed
US-11161841-B2 Modulators of proteolysis and associated methods of use ARVINAS OPERATIONS, INC. (US) 2021-11-02 — — US disclosed
CN-112218859-A Modulators of proteolysis and related methods of use 阿尔维纳斯运营股份有限公司 2021-01-12 — — CN disclosed
US-20190315732-A1 MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. 2019-10-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220370416-A1 COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF KRAS KRAS, MDM2, VHL ABCB1 1983/4885MEN1 1786/4885KMT2A 1765/4885
US-20190315732-A1 MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE MDM2, CRBN, VHL ABCB1 3863/4885MEN1 2058/4885KMT2A 1443/4885
US-20220402907-A1 MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE MDM2, CRBN, VHL ABCB1 3863/4885MEN1 2058/4885KMT2A 1443/4885
US-12552783-B2 Modulators of proteolysis and associated methods of use CRBN, ADRM1, MDM2 ABCB1 4185/4885MEN1 3384/4885KMT2A 1095/4885
US-11161841-B2 Modulators of proteolysis and associated methods of use MDM2, CRBN, VHL ABCB1 3863/4885MEN1 2058/4885KMT2A 1443/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.