Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 6/20 | 0.82 |
| ▸ | KDM6A | O15550 | 5/20 | 0.82 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.82 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.82 |
| ▸ | KDM5C | P41229 | 3/20 | 0.82 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.82 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.82 |
| ▸ | KDM5A | P29375 | 3/20 | 0.82 |
| ▸ | KDM4A | O75164 | 2/20 | 0.82 |
| ▸ | KDM4B | O94953 | 2/20 | 0.82 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.82 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.82 |
| ▸ | MAOB | P27338 | 2/20 | 0.82 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.82 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.82 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.82 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.82 |
| ▸ | MAOA | P21397 | 1/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10157115 | 0.90 | KDM6B (1.00) | KDM6BKDM6AKDM5BKDM2BKDM5C | |
| SCHEMBL29353127 | 0.90 | KDM6B (1.00) | KDM6BKDM6AKDM5BKDM2BKDM5C | |
| SCHEMBL29371558 | 0.90 | KDM6B (1.00) | KDM6BKDM6AKDM5BKDM2BKDM5C | |
| SCHEMBL17899150 | 0.89 | KDM6B (0.84) | KDM6BKDM6AKDM5BKDM2BKDM5C | |
| SCHEMBL25183825 | 0.89 | HDAC1 (0.89) | KDM6BKDM6AKDM5BKDM2BKDM5C | |
| SCHEMBL18159121 | 0.88 | KDM6B (0.85) | KDM6BKDM6AKDM5BKDM2BKDM5C | |
| SCHEMBL25507239 | 0.87 | KDM6A (0.79) | KDM6BKDM6AKDM5BKDM2BKDM5C | |
| SCHEMBL25507258 | 0.86 | KDM6A (0.78) | KDM6BKDM6AKDM5BKDM2BKDM5C | |
| SCHEMBL29409168 | 0.85 | KDM6B (1.00) | KDM6BKDM6AKDM5BKDM2BKDM5C | |
| SCHEMBL29373519 | 0.85 | KDM6B (1.00) | KDM6BKDM6AKDM5BKDM2BKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019200224-A1 | SYNERGISTIC DRUG COMBINATIONS PREDICTED FROM GENOMIC FEATURES AND SINGLE-AGENT RESPONSE PROFILES | THE BROAD INSTITUTE, INC. (US) | 2019-10-17 | — | — | WO | disclosed |