Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | BCL6 | P41182 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24405723 | 0.84 | GAA (0.39) | GAANPC1RAB9ALMNATSHR | |
| SCHEMBL21474179 | 0.82 | GAA (0.39) | GAAMTORNPC1RAB9ALMNA | |
| SCHEMBL23119712 | 0.81 | GAA (0.40) | GAAPIK3CANPC1RAB9ALMNA | |
| SCHEMBL30615457 | 0.79 | TNKS (0.40) | MCHR1GAANPC1LMNASMN1; SMN2 | |
| SCHEMBL21463426 | 0.79 | TNKS (0.40) | MCHR1GAANPC1LMNASMN1; SMN2 | |
| SCHEMBL24405756 | 0.77 | GAA (0.39) | GAAPIK3CANPC1RAB9ALMNA | |
| SCHEMBL29026387 | 0.75 | PGR (0.38) | GAAMTORPIK3CDPIK3CAPIK3CG | |
| SCHEMBL24405558 | 0.74 | PGR (0.43) | MTORPIK3CDPIK3CAPIK3CGNPC1 | |
| SCHEMBL24405534 | 0.74 | PGR (0.38) | MTORPIK3CDPIK3CAPIK3CGPGR | |
| SCHEMBL24405718 | 0.73 | PIK3CD (0.36) | GAAMTORPIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774739-B1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RAQUALIA PHARMA INC (JP) | 2022-05-11 | — | — | EP | disclosed |
| WO-2019198692-A1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RAQUALIA PHARMA INC. (JP) | 2019-10-17 | — | — | WO | disclosed |