Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21484499 | 0.80 | HRH3 (0.38) | HRH3LMNAALDH1A1TAAR1ALOX15 | |
| SCHEMBL14084800 | 0.76 | KDM5B (0.35) | HRH3ALDH1A1BRD4CREBBPCYP2C19 | |
| SCHEMBL1913121 | 0.71 | HRH3 (0.60) | HRH3LMNAALDH1A1TAAR1ALOX15 | |
| SCHEMBL14384748 | 0.66 | HRH3 (0.43) | HRH3LMNAALDH1A1TAAR1ALOX15 | |
| SCHEMBL14385625 | 0.66 | CPB2 (0.56) | HRH3LMNAALDH1A1TAAR1ALOX15 | |
| SCHEMBL2629278 | 0.65 | — | — | |
| SCHEMBL27317518 | 0.64 | HRH3 (0.47) | HRH3LMNAALDH1A1TAAR1ALOX15 | |
| SCHEMBL1908661 | 0.64 | CPB2 (0.43) | HRH3LMNAALDH1A1TAAR1ALOX15 | |
| SCHEMBL16651034 | 0.63 | — | — | |
| SCHEMBL1908703 | 0.63 | HRH3 (0.41) | HRH3LMNAALDH1A1TAAR1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019200202-A1 | ANTAGONISTS OF HUMAN INTEGRIN (ALPHA4)(BETA7) | MORPHIC THERAPEUTIC, INC. (US) | 2019-10-17 | — | — | WO | disclosed |