Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 3/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | VDR | P11473 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21475993 | 0.92 | FFAR1 (0.48) | FFAR1CYP11B1CYP11B2CNR2HDAC1 | |
| SCHEMBL21476085 | 0.87 | CYP11B1 (0.41) | CTSAFFAR1CYP11B1CYP11B2CNR2 | |
| SCHEMBL21475921 | 0.82 | CYP11B1 (0.42) | FFAR1CYP11B1CYP11B2CNR2HDAC1 | |
| SCHEMBL31303333 | 0.78 | CTSA (0.54) | CTSA | |
| SCHEMBL21459985 | 0.78 | CTSA (0.54) | CTSA | |
| SCHEMBL21459983 | 0.78 | CTSA (0.54) | CTSA | |
| SCHEMBL21475996 | 0.77 | FFAR1 (0.64) | FFAR1 | |
| SCHEMBL21476056 | 0.77 | FFAR1 (0.52) | FFAR1 | |
| SCHEMBL21476702 | 0.76 | FFAR1 (0.66) | FFAR1SIRT2 | |
| SCHEMBL3745313 | 0.73 | CYP11B2 (0.48) | CTSAFFAR1CYP11B1CYP11B2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019200202-A1 | ANTAGONISTS OF HUMAN INTEGRIN (ALPHA4)(BETA7) | MORPHIC THERAPEUTIC, INC. (US) | 2019-10-17 | — | — | WO | disclosed |