Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.68 |
| ▸ | RAF1 | P04049 | 18/20 | 0.68 |
| ▸ | ARAF | P10398 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20323725 | 0.93 | BRAF (0.70) | BRAFRAF1ARAF | |
| SCHEMBL20324231 | 0.91 | BRAF (0.72) | BRAFRAF1ARAF | |
| SCHEMBL20314619 | 0.82 | BRAF (0.59) | BRAFRAF1ARAF | |
| SCHEMBL19879433 | 0.81 | BRAF (1.00) | BRAFRAF1ARAF | |
| SCHEMBL15085295 | 0.81 | BRAF (1.00) | BRAFRAF1ARAF | |
| SCHEMBL22266314 | 0.81 | BRAF (0.58) | BRAFRAF1ARAF | |
| SCHEMBL22266355 | 0.79 | BRAF (0.56) | BRAFRAF1ARAF | |
| SCHEMBL20404673 | 0.78 | BRAF (0.68) | BRAFRAF1ARAF | |
| Lifirafenib SCHEMBL24916576 | 0.76 | BRAF (1.00) | BRAFRAF1ARAF | |
| Lifirafenib SCHEMBL20129833 | 0.76 | BRAF (1.00) | BRAFRAF1ARAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019199816-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | ARVINAS OPERATIONS, INC. (US) | 2019-10-17 | — | — | WO | disclosed |