Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 2/20 | 0.55 |
| ▸ | CDK14 | O94921 | 5/20 | 0.54 |
| ▸ | CCNY | Q8ND76 | 5/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.54 |
| ▸ | PIP4K2A | P48426 | 5/20 | 0.52 |
| ▸ | PIP4K2B | P78356 | 5/20 | 0.52 |
| ▸ | CDK7 | P50613 | 3/20 | 0.50 |
| ▸ | CCNH | P51946 | 2/20 | 0.50 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.50 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CDK9 | P50750 | 2/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21282715 | 0.86 | IRAK1 (0.57) | IRAK1CDK14CCNYMAPK8MAPK9 | |
| SCHEMBL28421380 | 0.86 | IRAK1 (0.57) | IRAK1CDK14CCNYMAPK8MAPK9 | |
| SCHEMBL28928229 | 0.83 | IRAK1 (0.56) | IRAK1CDK14CCNYMAPK8MAPK9 | |
| SCHEMBL21481476 | 0.82 | ACKR3 (0.47) | CDK14CCNYPIP4K2APIP4K2BACKR3 | |
| SCHEMBL31069490 | 0.82 | PARP1 (0.65) | IRAK1CDK14CCNYMAPK8MAPK9 | |
| SCHEMBL30731007 | 0.82 | PARP1 (0.65) | IRAK1CDK14CCNYMAPK8MAPK9 | |
| SCHEMBL21481530 | 0.81 | CDK14 (0.50) | IRAK1CDK14CCNYMAPK8MAPK9 | |
| SCHEMBL21344948 | 0.81 | DHODH (0.56) | CDK14CCNYPIP4K2APIP4K2BCDK7 | |
| SCHEMBL30716322 | 0.81 | CREBBP (0.55) | IRAK1CDK14CCNYMAPK8MAPK9 | |
| SCHEMBL26696906 | 0.81 | CREBBP (0.55) | IRAK1CDK14CCNYMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858937-B2 | Substituted pyrazolo[1,5-a]pyrimidines and pyrazolo[1,5-a][1,3,5]triazines as CDK inhibitors | QURIENT CO., LTD. (KR) | 2024-01-02 | — | — | US | disclosed |
| US-20210139483-A1 | PHARMACEUTICALLY ACTIVE PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES | LEAD DISCOVERY CENTER GMBH (DE) | 2021-05-13 | — | — | US | disclosed |
| WO-2019197546-A1 | PHARMACEUTICALLY ACTIVE PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES | QURIENT CO., LTD. (KR) | 2019-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11858937-B2 | Substituted pyrazolo[1,5-a]pyrimidines and pyrazolo[1,5-a][1,3,5]triazines as CDK inhibitors | CDKL5, CDK15, CDK5 | IRAK1 164/4885CDK14 26/4885CCNY 46/4885 |
| US-20210139483-A1 | PHARMACEUTICALLY ACTIVE PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES | IL5, THPO, TYMP | IRAK1 276/4885CDK14 577/4885CCNY 597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.