Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.74 |
| ▸ | RAB9A | P51151 | 3/20 | 0.74 |
| ▸ | NPC1 | O15118 | 1/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5634354 | 0.81 | MAPK13 (0.76) | SMN1; SMN2RAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL5634600 | 0.79 | NPC1 (0.70) | SMN1; SMN2RAB9ANPC1MAPK14MAPK13 | |
| SCHEMBL5634498 | 0.79 | NPC1 (0.65) | SMN1; SMN2RAB9ANPC1MAPK14MAPK13 | |
| SCHEMBL5635683 | 0.78 | NPC1 (0.68) | SMN1; SMN2RAB9ANPC1MAPK14MAPK13 | |
| SCHEMBL5634107 | 0.77 | NPC1 (0.67) | SMN1; SMN2RAB9ANPC1MAPK14MAPK13 | |
| SCHEMBL5634392 | 0.77 | MAPK13 (0.76) | SMN1; SMN2RAB9ANPC1MAPK14MAPK13 | |
| SCHEMBL5634236 | 0.76 | NPC1 (0.64) | SMN1; SMN2RAB9ANPC1MAPK14MAPK13 | |
| SCHEMBL5635186 | 0.76 | NPC1 (0.64) | SMN1; SMN2RAB9ANPC1MAPK14MAPK13 | |
| SCHEMBL30729284 | 0.75 | CHRNA7 (0.61) | SMN1; SMN2RAB9ANPC1KDM4EHPGD | |
| SCHEMBL3408291 | 0.75 | CHRNA7 (0.61) | SMN1; SMN2RAB9ANPC1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2732819-B1 | Compounds that enhance Atoh-1 expression | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2019-10-16 | — | — | EP | disclosed |