Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.51 |
| ▸ | CDK2 | P24941 | 5/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30729284 | 1.00 | CHRNA7 (0.61) | CHRNA7RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL25609668 | 0.82 | CCNA2 (0.77) | CHRNA7RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL31415148 | 0.82 | CCNA2 (0.77) | CHRNA7RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL20142368 | 0.79 | MAPT (0.70) | CHRNA7RAB9ASMN1; SMN2MAPTCDK5 | |
| SCHEMBL20142432 | 0.78 | CCNA2 (0.80) | CHRNA7RAB9AMAPTCDK5CDK5R1 | |
| SCHEMBL20142500 | 0.77 | GSK3A (0.77) | CHRNA7RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL20141867 | 0.76 | GSK3A (0.63) | CHRNA7RAB9AMAPTCDK5CDK5R1 | |
| SCHEMBL6191118 | 0.76 | CCNA2 (0.75) | CDK5CDK5R1CCNA2CDK2GSK3B | |
| SCHEMBL27706920 | 0.76 | RAB9A (0.80) | CHRNA7RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL21481994 | 0.75 | SMN1; SMN2 (0.74) | RAB9ASMN1; SMN2KDM4EMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170189477-A1 | Methods and Compositions of P27KIP1 Transcriptional Modulators | NIH-DEITR | 2017-07-06 | — | — | US | claimed |
| US-9572815-B2 | Methods and compositions of p27KIP1 transcriptional modulators | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2017-02-21 | — | — | US | claimed |
| US-20160030445-A1 | METHODS AND COMPOSITIONS OF P27KIP1 TRANSCRIPTIONAL MODULATORS | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2016-02-04 | — | — | US | claimed |
| EP-2254572-A2 | COMPOUNDS THAT ENHANCE ATOH-1 EXPRESSION | Massachusetts Eye & Ear Infirmary (US) | 2010-12-01 | — | — | EP | claimed |
| US-20090232780-A1 | COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-09-17 | — | — | US | claimed |
| WO-2009100438-A2 | COMPOUNDS THAT ENHANCE ATOH-1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-08-13 | — | — | WO | claimed |
| US-20250099539-A1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS | MASSACHUSETTS EYE AND EAR INFIRMARY | 2025-03-27 | — | — | US | disclosed |
| US-12239651-B2 | Treatment of hearing loss | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2025-03-04 | — | — | US | disclosed |
| US-12156899-B2 | Methods and compositions for regenerating hair cells and/or supporting cells | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2024-12-03 | — | — | US | disclosed |
| US-20240299432-A1 | TREATMENT OF HEARING LOSS | MASSACHUSETTS EYE AND EAR INFIRMARY | 2024-09-12 | — | — | US | disclosed |
| US-12043653-B2 | Efficient delivery of therapeutic molecules to cells of the inner ear | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2024-07-23 | — | — | US | disclosed |
| US-11963968-B2 | Treatment of hearing loss | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2024-04-23 | — | — | US | disclosed |
| US-20240100079-A1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS IN THE INNER EAR OF ADULT MAMMALS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-03-28 | — | — | US | disclosed |
| US-8188131-B2 | Compounds that enhance Atoh1 expression | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188131-B2 | Compounds that enhance Atoh1 expression | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188131-B2 | Compounds that enhance Atoh1 expression | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2012-05-29 | — | — | US | disclosed |
| US-20090232780-A1 | COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-09-17 | — | — | US | disclosed |
| US-20090232780-A1 | COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-09-17 | — | — | US | disclosed |
| US-20090232780-A1 | COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-09-17 | — | — | US | disclosed |
| WO-2009100438-A2 | COMPOUNDS THAT ENHANCE ATOH-1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240299432-A1 | TREATMENT OF HEARING LOSS | HES1, NOTCH1, NOTCH4 | CHRNA7 4401/4885RAB9A 1434/4885SMN1; SMN2 3919/4885 |
| US-12043653-B2 | Efficient delivery of therapeutic molecules to cells of the inner ear | HES1, NOTCH1, NOTCH2 | CHRNA7 4257/4885RAB9A 2455/4885SMN1; SMN2 4645/4885 |
| US-20170189477-A1 | Methods and Compositions of P27KIP1 Transcriptional Modulators | WNT1, CTNNB1, CTNNBL1 | CHRNA7 3692/4885RAB9A 4314/4885SMN1; SMN2 4085/4885 |
| US-12156899-B2 | Methods and compositions for regenerating hair cells and/or supporting cells | HES1, NOTCH1, NOTCH4 | CHRNA7 3201/4885RAB9A 3020/4885SMN1; SMN2 4643/4885 |
| US-20250099539-A1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS | HES1, NOTCH1, NOTCH4 | CHRNA7 3201/4885RAB9A 3020/4885SMN1; SMN2 4643/4885 |
| US-20160030445-A1 | METHODS AND COMPOSITIONS OF P27KIP1 TRANSCRIPTIONAL MODULATORS | WNT1, CTNNB1, CTNNBL1 | CHRNA7 3918/4885RAB9A 4168/4885SMN1; SMN2 4190/4885 |
| US-20090232780-A1 | COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION | DACH1, EZH1, CREBBP | CHRNA7 1783/4885RAB9A 3293/4885SMN1; SMN2 2179/4885 |
| US-12239651-B2 | Treatment of hearing loss | HES1, NOTCH1, NOTCH4 | CHRNA7 4401/4885RAB9A 1434/4885SMN1; SMN2 3919/4885 |
| US-11963968-B2 | Treatment of hearing loss | HES1, NOTCH1, NOTCH4 | CHRNA7 4401/4885RAB9A 1434/4885SMN1; SMN2 3919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.