Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.60 |
| ▸ | MTOR | P42345 | 16/20 | 0.60 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.60 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.60 |
| ▸ | PRKDC | P78527 | 2/20 | 0.60 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.60 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.60 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.60 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.60 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.60 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.60 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.48 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21462147 | 0.88 | PIK3CA (0.59) | PIK3CAMTORPIK3R1PIK3CDPIK3C2B | |
| SCHEMBL21486201 | 0.85 | PIK3CA (0.55) | PIK3CAMTORPIK3R1CARM1 | |
| SCHEMBL21482272 | 0.82 | CARM1 (0.61) | PIK3CACARM1 | |
| SCHEMBL21482290 | 0.79 | PIK3CA (0.58) | PIK3CAMTORPIK3R1CARM1 | |
| Bimiralisib SCHEMBL29352266 | 0.77 | PIK3CA (1.00) | PIK3CAMTORPIK3R1PIK3CDPIK3C2B | |
| Bimiralisib SCHEMBL1309049 | 0.77 | PIK3CA (1.00) | PIK3CAMTORPIK3R1PIK3CDPIK3C2B | |
| SCHEMBL21482282 | 0.77 | PIK3CA (0.57) | PIK3CAMTORPIK3R1CARM1 | |
| SCHEMBL21482280 | 0.76 | CARM1 (0.62) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| Bimiralisib SCHEMBL29644978 | 0.76 | PIK3CA (0.98) | PIK3CAMTORPIK3R1PIK3CDPIK3C2B | |
| Bimiralisib SCHEMBL18428577 | 0.76 | PIK3CA (0.98) | PIK3CAMTORPIK3R1PIK3CDPIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019196720-A1 | ARGININE METHYLTRANSFERASE INHIBITOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | 中国科学院上海药物研究所 | 2019-10-17 | — | — | WO | disclosed |