SCHEMBL21482287

SCHEMBL21482287

CNCCNCc1cccc(-c2nc(-c3c(C)noc3C)nc(N3CCOCC3)n2)c1

nearest known ligand 0.75

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CARM1 Q86X55 20/20 0.75
PRMT6 Q96LA8 1/20 0.58
PRMT8 Q9NR22 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21482272 0.87 CARM1 (0.61) CARM1
SCHEMBL21465840 0.85 CARM1 (1.00) CARM1PRMT6PRMT8
SCHEMBL21482290 0.83 PIK3CA (0.58) CARM1
SCHEMBL21486201 0.81 PIK3CA (0.55) CARM1
SCHEMBL21482270 0.78 CARM1 (1.00) CARM1PRMT6PRMT8
SCHEMBL21482273 0.77 CARM1 (0.61) CARM1
SCHEMBL21462151 0.77 CARM1 (1.00) CARM1PRMT6PRMT8
SCHEMBL21482262 0.77 CARM1 (1.00) CARM1PRMT6PRMT8
SCHEMBL21482332 0.76 CARM1 (1.00) CARM1PRMT6PRMT8
SCHEMBL21482282 0.76 PIK3CA (0.57) CARM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019196720-A1 ARGININE METHYLTRANSFERASE INHIBITOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF 中国科学院上海药物研究所 2019-10-17 WO disclosed