Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 14/20 | 0.42 |
| ▸ | CDK9 | P50750 | 13/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23381749 | 0.83 | CDK9 (0.46) | CDK2CDK9CCNE1CDK5CDK5R1 | |
| SCHEMBL23382180 | 0.82 | CDK9 (0.45) | CDK2CDK9CCNE1CDK5CDK5R1 | |
| SCHEMBL23382008 | 0.80 | CDK9 (0.42) | CDK2CDK9CCNE1CDK5CDK5R1 | |
| SCHEMBL23382145 | 0.79 | CNR1 (0.44) | CDK2CDK9SMPD3CNR1CNR2 | |
| SCHEMBL23382029 | 0.78 | CDK9 (0.41) | CDK2CDK9CCNE1CDK5CDK5R1 | |
| SCHEMBL23382112 | 0.77 | CKS1B (0.41) | CDK2CDK9CCNE1CDK5CDK7 | |
| SCHEMBL23381671 | 0.77 | CDK2 (0.56) | CDK2CDK9CCNE1CDK5CDK5R1 | |
| SCHEMBL23381992 | 0.75 | CDK9 (0.51) | CDK2CDK9CCNE1CDK5CDK5R1 | |
| SCHEMBL23381996 | 0.75 | CDK9 (0.51) | CDK2CDK9CCNE1CDK5CDK5R1 | |
| SCHEMBL23382195 | 0.75 | CDK9 (0.51) | CDK2CDK9CCNE1CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019197549-A1 | PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITOR OF CYCLIN DEPENDENT KINASE | QURIENT CO., LTD. (KR) | 2019-10-17 | — | — | WO | disclosed |